Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus

Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus

Abstract Diabetes mellitus (DM) is associated with a dysfunctional intestinal barrier and an increased risk for systemic infection and inflammation in people, though the pathogenic mechanisms leading to this are poorly understood. Using a canine model of DM, we showed that the peroxisomal proliferat...

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Autores principales: Katti R. Crakes, Jully Pires, Nina Quach, Riley E. Ellis-Reis, Rachel Greathouse, Kathyrnne A. Chittum, Jörg M. Steiner, Patricia Pesavento, Stanley L. Marks, Satya Dandekar, Chen Gilor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/fc8522dc657f47b5bd02084f12d335f5
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