Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which is restricted by glutathione peroxidase 4 in the inte...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc87842ee61c451c8bde60fdd9105dee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fc87842ee61c451c8bde60fdd9105dee
record_format	dspace
spelling	oai:doaj.org-article:fc87842ee61c451c8bde60fdd9105dee2021-12-02T16:49:59ZDietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease10.1038/s41467-020-15646-62041-1723https://doaj.org/article/fc87842ee61c451c8bde60fdd9105dee2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15646-6https://doaj.org/toc/2041-1723Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which is restricted by glutathione peroxidase 4 in the intestinal epithelium.Lisa MayrFelix GrabherrJulian SchwärzlerIsabelle ReitmeierFelix SommerThomas GehmacherLukas NiederreiterGui-Wei HeBarbara RuderKai T. R. KunzPiotr TymoszukRichard HilbeDavid HaschkaClemens FeistritzerRomana R. GernerBarbara EnrichNicole PrzysieckiMarkus SeifertMarkus A. KellerGeorg OberhuberSusanne SprungQitao RanRobert KochMaria EffenbergerIvan TancevskiHeinz ZollerAlexander R. MoschenGünter WeissChristoph BeckerPhilip RosenstielArthur KaserHerbert TilgTimon E. AdolphNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa Mayr Felix Grabherr Julian Schwärzler Isabelle Reitmeier Felix Sommer Thomas Gehmacher Lukas Niederreiter Gui-Wei He Barbara Ruder Kai T. R. Kunz Piotr Tymoszuk Richard Hilbe David Haschka Clemens Feistritzer Romana R. Gerner Barbara Enrich Nicole Przysiecki Markus Seifert Markus A. Keller Georg Oberhuber Susanne Sprung Qitao Ran Robert Koch Maria Effenberger Ivan Tancevski Heinz Zoller Alexander R. Moschen Günter Weiss Christoph Becker Philip Rosenstiel Arthur Kaser Herbert Tilg Timon E. Adolph Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
description	Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which is restricted by glutathione peroxidase 4 in the intestinal epithelium.
format	article
author	Lisa Mayr Felix Grabherr Julian Schwärzler Isabelle Reitmeier Felix Sommer Thomas Gehmacher Lukas Niederreiter Gui-Wei He Barbara Ruder Kai T. R. Kunz Piotr Tymoszuk Richard Hilbe David Haschka Clemens Feistritzer Romana R. Gerner Barbara Enrich Nicole Przysiecki Markus Seifert Markus A. Keller Georg Oberhuber Susanne Sprung Qitao Ran Robert Koch Maria Effenberger Ivan Tancevski Heinz Zoller Alexander R. Moschen Günter Weiss Christoph Becker Philip Rosenstiel Arthur Kaser Herbert Tilg Timon E. Adolph
author_facet	Lisa Mayr Felix Grabherr Julian Schwärzler Isabelle Reitmeier Felix Sommer Thomas Gehmacher Lukas Niederreiter Gui-Wei He Barbara Ruder Kai T. R. Kunz Piotr Tymoszuk Richard Hilbe David Haschka Clemens Feistritzer Romana R. Gerner Barbara Enrich Nicole Przysiecki Markus Seifert Markus A. Keller Georg Oberhuber Susanne Sprung Qitao Ran Robert Koch Maria Effenberger Ivan Tancevski Heinz Zoller Alexander R. Moschen Günter Weiss Christoph Becker Philip Rosenstiel Arthur Kaser Herbert Tilg Timon E. Adolph
author_sort	Lisa Mayr
title	Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
title_short	Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
title_full	Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
title_fullStr	Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
title_full_unstemmed	Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
title_sort	dietary lipids fuel gpx4-restricted enteritis resembling crohn’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fc87842ee61c451c8bde60fdd9105dee
work_keys_str_mv	AT lisamayr dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT felixgrabherr dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT julianschwarzler dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT isabellereitmeier dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT felixsommer dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT thomasgehmacher dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT lukasniederreiter dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT guiweihe dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT barbararuder dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT kaitrkunz dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT piotrtymoszuk dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT richardhilbe dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT davidhaschka dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT clemensfeistritzer dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT romanargerner dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT barbaraenrich dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT nicoleprzysiecki dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT markusseifert dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT markusakeller dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT georgoberhuber dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT susannesprung dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT qitaoran dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT robertkoch dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT mariaeffenberger dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT ivantancevski dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT heinzzoller dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT alexanderrmoschen dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT gunterweiss dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT christophbecker dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT philiprosenstiel dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT arthurkaser dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT herberttilg dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease AT timoneadolph dietarylipidsfuelgpx4restrictedenteritisresemblingcrohnsdisease
_version_	1718383195573977088

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Ejemplares similares