Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma

Jyoti Verma,1,2 Sumit Lal,1 Cornelis JF Van Noorden31Department of Medicine, Harvard Medical School, 2Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA; 3Department of Cell Biology and Histology, Academic Medical Centre, University of Amster...

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Autores principales:	Verma J, Lal S, Van Noorden CJF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fc88d95eb93b4b3eb008d1e6548b1459
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spelling	oai:doaj.org-article:fc88d95eb93b4b3eb008d1e6548b14592021-12-02T07:22:53ZNanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma1178-2013https://doaj.org/article/fc88d95eb93b4b3eb008d1e6548b14592014-06-01T00:00:00Zhttp://www.dovepress.com/nanoparticles-for-hyperthermic-therapy-synthesis-strategies-and-applic-a17150https://doaj.org/toc/1178-2013 Jyoti Verma,1,2 Sumit Lal,1 Cornelis JF Van Noorden31Department of Medicine, Harvard Medical School, 2Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA; 3Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The NetherlandsAbstract: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.Keywords: hyperthermia, targeted drug delivery, SPIONs, gold nanorods, carbon nanotubesVerma JLal SVan Noorden CJFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2863-2877 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Verma J Lal S Van Noorden CJF Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
description	Jyoti Verma,1,2 Sumit Lal,1 Cornelis JF Van Noorden31Department of Medicine, Harvard Medical School, 2Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA; 3Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The NetherlandsAbstract: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.Keywords: hyperthermia, targeted drug delivery, SPIONs, gold nanorods, carbon nanotubes
format	article
author	Verma J Lal S Van Noorden CJF
author_facet	Verma J Lal S Van Noorden CJF
author_sort	Verma J
title	Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
title_short	Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
title_full	Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
title_fullStr	Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
title_full_unstemmed	Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
title_sort	nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/fc88d95eb93b4b3eb008d1e6548b1459
work_keys_str_mv	AT vermaj nanoparticlesforhyperthermictherapysynthesisstrategiesandapplicationsinglioblastoma AT lals nanoparticlesforhyperthermictherapysynthesisstrategiesandapplicationsinglioblastoma AT vannoordencjf nanoparticlesforhyperthermictherapysynthesisstrategiesandapplicationsinglioblastoma
_version_	1718399496292925440

Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma

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