A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events

Alexandria N Hughes, Julia Thom Oxford Department of Biological Sciences, Biomolecular Research Center, Boise State University, Boise, ID, USA Abstract: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, a...

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Autores principales:	Hughes AN, Oxford JT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/fc8c55cb70d64f16a4260f289772c520
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spelling	oai:doaj.org-article:fc8c55cb70d64f16a4260f289772c5202021-12-02T03:10:52ZA lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events1179-1535https://doaj.org/article/fc8c55cb70d64f16a4260f289772c5202014-03-01T00:00:00Zhttp://www.dovepress.com/a-lipid-rich-gestational-diet-predisposes-offspring-to-nonalcoholic-fa-a16029https://doaj.org/toc/1179-1535 Alexandria N Hughes, Julia Thom Oxford Department of Biological Sciences, Biomolecular Research Center, Boise State University, Boise, ID, USA Abstract: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, and it is increasing worldwide. Recently, the role of lipid-rich maternal gestational nutrition in spurring the development of NAFLD among offspring has been indicated. Fetal predisposition to NAFLD involves numerous physiological reroutings that are initiated by increased delivery of nonesterified fatty acids to the fetal liver. Hampered ß-oxidation, uncontrolled oxidative stress, increased triacylglycerol synthesis, and the endoplasmic reticulum unfolded protein response are all implicated in sculpting a hepatic phenotype with a propensity to develop NAFLD in the postnatal state. This review suggests a mechanism that integrates outcomes reported by a variety of studies conducted in an analysis of fetal hepatic metabolic capacity amid the maternal consumption of a high-fat diet. Potential preventive measures and therapies for use both as part of prenatal nutrition and for those at risk for the development of NAFLD are also discussed. Keywords: nonalcoholic fatty liver disease, fetal–maternal diet, hepatocyte, oxidative stressHughes ANOxford JTDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2014, Iss default, Pp 15-23 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Hughes AN Oxford JT A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
description	Alexandria N Hughes, Julia Thom Oxford Department of Biological Sciences, Biomolecular Research Center, Boise State University, Boise, ID, USA Abstract: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, and it is increasing worldwide. Recently, the role of lipid-rich maternal gestational nutrition in spurring the development of NAFLD among offspring has been indicated. Fetal predisposition to NAFLD involves numerous physiological reroutings that are initiated by increased delivery of nonesterified fatty acids to the fetal liver. Hampered ß-oxidation, uncontrolled oxidative stress, increased triacylglycerol synthesis, and the endoplasmic reticulum unfolded protein response are all implicated in sculpting a hepatic phenotype with a propensity to develop NAFLD in the postnatal state. This review suggests a mechanism that integrates outcomes reported by a variety of studies conducted in an analysis of fetal hepatic metabolic capacity amid the maternal consumption of a high-fat diet. Potential preventive measures and therapies for use both as part of prenatal nutrition and for those at risk for the development of NAFLD are also discussed. Keywords: nonalcoholic fatty liver disease, fetal–maternal diet, hepatocyte, oxidative stress
format	article
author	Hughes AN Oxford JT
author_facet	Hughes AN Oxford JT
author_sort	Hughes AN
title	A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
title_short	A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
title_full	A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
title_fullStr	A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
title_full_unstemmed	A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
title_sort	lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/fc8c55cb70d64f16a4260f289772c520
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A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events

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