Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants

Abstract Growth rates importantly determine developmental time and are, therefore, a key variable of a species' life history. A widely used method to reconstruct growth rates and to estimate age at death in extant and particularly in fossil vertebrates is the analysis of bone tissue apposition...

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Autores principales:	Teresa Calderón, Walter Arnold, Gabrielle Stalder, Johanna Painer, Meike Köhler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc8e7f929e0a4c59ba44795c9318179a
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spelling	oai:doaj.org-article:fc8e7f929e0a4c59ba44795c9318179a2021-12-02T18:33:58ZLabelling experiments in red deer provide a general model for early bone growth dynamics in ruminants10.1038/s41598-021-93547-42045-2322https://doaj.org/article/fc8e7f929e0a4c59ba44795c9318179a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93547-4https://doaj.org/toc/2045-2322Abstract Growth rates importantly determine developmental time and are, therefore, a key variable of a species' life history. A widely used method to reconstruct growth rates and to estimate age at death in extant and particularly in fossil vertebrates is the analysis of bone tissue apposition rates. Lines of arrested growth (LAGs) are of special interest here, as they indicate a halt in bone growth. However, although of great importance, the time intervals between, and particularly the reason of growth arrests remains unknown. Therefore, experiments are increasingly called for to calibrate growth rates with tissue types and life history events, and to provide reliable measurements of the time involved in the formation of LAGs. Based on in vivo bone labelling, we calibrated periods of bone tissue apposition, growth arrest, drift and resorption over the period from birth to post-weaning in a large mammal, the red deer. We found that bone growth rates tightly matched the daily weight gain curve, i.e. decreased with age, with two discrete periods of growth rate disruption that coincided with the life history events birth and weaning, that were visually recognisable in bone tissue as either partial LAGs or annuli. Our study identified for the first time in a large mammal a general pattern for juvenile bone growth rates, including periods of growth arrest. The tight correlation between daily weight gain and bone tissue apposition suggests that the red deer bone growth model is valid for ruminants in general where the daily weight gain curve is comparable.Teresa CalderónWalter ArnoldGabrielle StalderJohanna PainerMeike KöhlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Teresa Calderón Walter Arnold Gabrielle Stalder Johanna Painer Meike Köhler Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
description	Abstract Growth rates importantly determine developmental time and are, therefore, a key variable of a species' life history. A widely used method to reconstruct growth rates and to estimate age at death in extant and particularly in fossil vertebrates is the analysis of bone tissue apposition rates. Lines of arrested growth (LAGs) are of special interest here, as they indicate a halt in bone growth. However, although of great importance, the time intervals between, and particularly the reason of growth arrests remains unknown. Therefore, experiments are increasingly called for to calibrate growth rates with tissue types and life history events, and to provide reliable measurements of the time involved in the formation of LAGs. Based on in vivo bone labelling, we calibrated periods of bone tissue apposition, growth arrest, drift and resorption over the period from birth to post-weaning in a large mammal, the red deer. We found that bone growth rates tightly matched the daily weight gain curve, i.e. decreased with age, with two discrete periods of growth rate disruption that coincided with the life history events birth and weaning, that were visually recognisable in bone tissue as either partial LAGs or annuli. Our study identified for the first time in a large mammal a general pattern for juvenile bone growth rates, including periods of growth arrest. The tight correlation between daily weight gain and bone tissue apposition suggests that the red deer bone growth model is valid for ruminants in general where the daily weight gain curve is comparable.
format	article
author	Teresa Calderón Walter Arnold Gabrielle Stalder Johanna Painer Meike Köhler
author_facet	Teresa Calderón Walter Arnold Gabrielle Stalder Johanna Painer Meike Köhler
author_sort	Teresa Calderón
title	Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
title_short	Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
title_full	Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
title_fullStr	Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
title_full_unstemmed	Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
title_sort	labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc8e7f929e0a4c59ba44795c9318179a
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Labelling experiments in red deer provide a general model for early bone growth dynamics in ruminants

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