Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism

ABSTRACT Most microorganisms maintain strict control of nutrient assimilation pathways to ensure that they preferentially use compounds that generate the most energy or are most efficiently catabolized. In doing so, they avoid potentially inefficient conflicts between parallel catabolic and metaboli...

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Autor principal:	Michael C. Lorenz
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fc8f4de0246a48eaafd953afa49eaf44
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spelling	oai:doaj.org-article:fc8f4de0246a48eaafd953afa49eaf442021-11-15T15:40:25ZCarbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism10.1128/mBio.00034-132150-7511https://doaj.org/article/fc8f4de0246a48eaafd953afa49eaf442013-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00034-13https://doaj.org/toc/2150-7511ABSTRACT Most microorganisms maintain strict control of nutrient assimilation pathways to ensure that they preferentially use compounds that generate the most energy or are most efficiently catabolized. In doing so, they avoid potentially inefficient conflicts between parallel catabolic and metabolic pathways. The regulation of carbon source utilization in a wide array of bacterial and fungal species involves both transcriptional and posttranscriptional mechanisms, and while the details can vary significantly, carbon catabolite control is widely conserved. In many fungi, the posttranslational aspect (carbon catabolite inactivation [CCI]) involves the ubiquitin-mediated degradation of catabolic enzymes for poor carbon sources when a preferred one (glucose) becomes available. A recent article presents evidence for a surprising exception to CCI in the fungal pathogen Candida albicans, an organism that makes use of gluconeogenic carbon sources during infection (D. Sandai, Z. Yin, L. Selway, D. Stead, J. Walker, M. D. Leach, I. Bohovych, I. V. Ene, S. Kastora, S. Budge, C. A. Munro, F. C. Odds, N. A. Gow, and A. J. Brown, mBio 3[6]:e00495-12). In vitro, addition of glucose to cells grown in a poor carbon source rapidly represses transcripts encoding gluconeogenic and glyoxylate cycle enzymes, such as phosphoenolpyruvate carboxykinase (Pck1p) and isocitrate lyase (Icl1p), in both C. albicans and Saccharomyces cerevisiae. Yet, uniquely, the C. albicans proteins persist, permitting parallel assimilation of multiple carbon sources, likely because they lack consensus ubiquitination sites found in the yeast homologs. Indeed, the yeast proteins are rapidly degraded when expressed in C. albicans, indicating a conservation of the machinery needed for CCI. How this surprising metabolic twist contributes to fungal commensalism or pathogenesis remains an open question.Michael C. LorenzAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 1 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Michael C. Lorenz Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
description	ABSTRACT Most microorganisms maintain strict control of nutrient assimilation pathways to ensure that they preferentially use compounds that generate the most energy or are most efficiently catabolized. In doing so, they avoid potentially inefficient conflicts between parallel catabolic and metabolic pathways. The regulation of carbon source utilization in a wide array of bacterial and fungal species involves both transcriptional and posttranscriptional mechanisms, and while the details can vary significantly, carbon catabolite control is widely conserved. In many fungi, the posttranslational aspect (carbon catabolite inactivation [CCI]) involves the ubiquitin-mediated degradation of catabolic enzymes for poor carbon sources when a preferred one (glucose) becomes available. A recent article presents evidence for a surprising exception to CCI in the fungal pathogen Candida albicans, an organism that makes use of gluconeogenic carbon sources during infection (D. Sandai, Z. Yin, L. Selway, D. Stead, J. Walker, M. D. Leach, I. Bohovych, I. V. Ene, S. Kastora, S. Budge, C. A. Munro, F. C. Odds, N. A. Gow, and A. J. Brown, mBio 3[6]:e00495-12). In vitro, addition of glucose to cells grown in a poor carbon source rapidly represses transcripts encoding gluconeogenic and glyoxylate cycle enzymes, such as phosphoenolpyruvate carboxykinase (Pck1p) and isocitrate lyase (Icl1p), in both C. albicans and Saccharomyces cerevisiae. Yet, uniquely, the C. albicans proteins persist, permitting parallel assimilation of multiple carbon sources, likely because they lack consensus ubiquitination sites found in the yeast homologs. Indeed, the yeast proteins are rapidly degraded when expressed in C. albicans, indicating a conservation of the machinery needed for CCI. How this surprising metabolic twist contributes to fungal commensalism or pathogenesis remains an open question.
format	article
author	Michael C. Lorenz
author_facet	Michael C. Lorenz
author_sort	Michael C. Lorenz
title	Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
title_short	Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
title_full	Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
title_fullStr	Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
title_full_unstemmed	Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism
title_sort	carbon catabolite control in <named-content content-type="genus-species">candida albicans</named-content>: new wrinkles in metabolism
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/fc8f4de0246a48eaafd953afa49eaf44
work_keys_str_mv	AT michaelclorenz carboncatabolitecontrolinnamedcontentcontenttypegenusspeciescandidaalbicansnamedcontentnewwrinklesinmetabolism
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Carbon Catabolite Control in <named-content content-type="genus-species">Candida albicans</named-content>: New Wrinkles in Metabolism

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