Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity

Abstract Recent studies indicate better efficacy and healthy tissue sparing with high dose-rate FLASH radiotherapy (FLASH-RT) cancer treatment. This technique delivers a prompt high radiation dose rather than fractional doses over time. While some suggest thresholds of > 40 Gy s−1 with a maximal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stephen E. Sampayan, Kristin C. Sampayan, George J. Caporaso, Yu-Jiuan Chen, Steve Falabella, Steven A. Hawkins, Jason Hearn, James A. Watson, Jan-Mark Zentler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc8fa27d92d54f74874a8983f5dd8171
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fc8fa27d92d54f74874a8983f5dd8171
record_format	dspace
spelling	oai:doaj.org-article:fc8fa27d92d54f74874a8983f5dd81712021-12-02T18:53:18ZMegavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity10.1038/s41598-021-95807-92045-2322https://doaj.org/article/fc8fa27d92d54f74874a8983f5dd81712021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95807-9https://doaj.org/toc/2045-2322Abstract Recent studies indicate better efficacy and healthy tissue sparing with high dose-rate FLASH radiotherapy (FLASH-RT) cancer treatment. This technique delivers a prompt high radiation dose rather than fractional doses over time. While some suggest thresholds of > 40 Gy s−1 with a maximal effect at > 100 Gy s−1, accumulated evidence shows that instantaneous dose-rate and irradiation time are critical. Mechanisms are still debated, but toxicity is minimized while inducing apoptosis in malignant tissue. Delivery technologies to date show that a capability gap exists with clinic scale, broad area, deep penetrating, high dose rate systems. Based on these trends, if FLASH-RT is adopted, it may become a dominant approach except in the least technologically advanced countries. The linear induction accelerator (LIA) developed for high instantaneous and high average dose-rate, species independent charged particle acceleration, has yet to be considered for this application. We review the status of LIA technology, explore the physics of bremsstrahlung-converter-target interactions and our work on stabilizing the electron beam. While the gradient of the LIA is low, we present our preliminary work to improve the gradient by an order of magnitude, presenting a point design for a multibeam FLASH-RT system using a single accelerator for application to conformal FLASH-RT.Stephen E. SampayanKristin C. SampayanGeorge J. CaporasoYu-Jiuan ChenSteve FalabellaSteven A. HawkinsJason HearnJames A. WatsonJan-Mark ZentlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephen E. Sampayan Kristin C. Sampayan George J. Caporaso Yu-Jiuan Chen Steve Falabella Steven A. Hawkins Jason Hearn James A. Watson Jan-Mark Zentler Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
description	Abstract Recent studies indicate better efficacy and healthy tissue sparing with high dose-rate FLASH radiotherapy (FLASH-RT) cancer treatment. This technique delivers a prompt high radiation dose rather than fractional doses over time. While some suggest thresholds of > 40 Gy s−1 with a maximal effect at > 100 Gy s−1, accumulated evidence shows that instantaneous dose-rate and irradiation time are critical. Mechanisms are still debated, but toxicity is minimized while inducing apoptosis in malignant tissue. Delivery technologies to date show that a capability gap exists with clinic scale, broad area, deep penetrating, high dose rate systems. Based on these trends, if FLASH-RT is adopted, it may become a dominant approach except in the least technologically advanced countries. The linear induction accelerator (LIA) developed for high instantaneous and high average dose-rate, species independent charged particle acceleration, has yet to be considered for this application. We review the status of LIA technology, explore the physics of bremsstrahlung-converter-target interactions and our work on stabilizing the electron beam. While the gradient of the LIA is low, we present our preliminary work to improve the gradient by an order of magnitude, presenting a point design for a multibeam FLASH-RT system using a single accelerator for application to conformal FLASH-RT.
format	article
author	Stephen E. Sampayan Kristin C. Sampayan George J. Caporaso Yu-Jiuan Chen Steve Falabella Steven A. Hawkins Jason Hearn James A. Watson Jan-Mark Zentler
author_facet	Stephen E. Sampayan Kristin C. Sampayan George J. Caporaso Yu-Jiuan Chen Steve Falabella Steven A. Hawkins Jason Hearn James A. Watson Jan-Mark Zentler
author_sort	Stephen E. Sampayan
title	Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
title_short	Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
title_full	Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
title_fullStr	Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
title_full_unstemmed	Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity
title_sort	megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a flash radiotherapy source to reduce acute toxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc8fa27d92d54f74874a8983f5dd8171
work_keys_str_mv	AT stephenesampayan megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT kristincsampayan megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT georgejcaporaso megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT yujiuanchen megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT stevefalabella megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT stevenahawkins megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT jasonhearn megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT jamesawatson megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity AT janmarkzentler megavoltbremsstrahlungmeasurementsfromlinearinductionacceleratorsdemonstratepossibleuseasaflashradiotherapysourcetoreduceacutetoxicity
_version_	1718377364731199488

Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity

Ejemplares similares