Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease

Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group...

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Autores principales:	Seong Jae Kim, Sun Hee Lee, In Bum Suh, Jae-Won Jang, Jin Hyeong Jhoo, Jung Hie Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc8fd5815e1d470eb087dc95c370be34
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spelling	oai:doaj.org-article:fc8fd5815e1d470eb087dc95c370be342021-12-02T15:55:08ZPositive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease10.1038/s41598-021-89521-92045-2322https://doaj.org/article/fc8fd5815e1d470eb087dc95c370be342021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89521-9https://doaj.org/toc/2045-2322Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients.Seong Jae KimSun Hee LeeIn Bum SuhJae-Won JangJin Hyeong JhooJung Hie LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
description	Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients.
format	article
author	Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee
author_facet	Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee
author_sort	Seong Jae Kim
title	Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_short	Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_full	Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_fullStr	Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_full_unstemmed	Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_sort	positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc8fd5815e1d470eb087dc95c370be34
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Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease

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