Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV

BACKGROUND AND OBJECTIVE: Infection with the hepatitis C virus (HCV) is leading cause of chronic liver disease. Cytokines play a key role in the modulation of immune response. Different single-nucleotide polymorphisms (SNPs) in TNF-Alpha promoter region have been identified. The aim of this study wa...

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Autores principales:	SH Baradaran Ghavami, SR Mohebbi, H Naghoosi, P Azimzadeh, E Tahaei, S Romani, SH Almasi, A Sanati, H Mirtalbi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	genotype chronic hepatitis c polymorphism single nucleotide tumor necrosis factor alpha genetics Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fc91a6fcddb94fd9a8c793ae3cad2ef4
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spelling	oai:doaj.org-article:fc91a6fcddb94fd9a8c793ae3cad2ef42021-11-10T08:53:26ZAssociation of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV1561-41072251-7170https://doaj.org/article/fc91a6fcddb94fd9a8c793ae3cad2ef42012-09-01T00:00:00Zhttp://jbums.org/article-1-4179-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Infection with the hepatitis C virus (HCV) is leading cause of chronic liver disease. Cytokines play a key role in the modulation of immune response. Different single-nucleotide polymorphisms (SNPs) in TNF-Alpha promoter region have been identified. The aim of this study was to investigate the association of TNF-α gene 1031 polymorphism with chronic hepatitis C patients.METHODS: This study is a case-control study. Genomic DNA of 119 HCV patients infected and 120 healthy controls were extracted and their genotypes were determined by PCR (Polymerase Chain Reaction) and RFLP (Restriction Fragment Length Polymorphism). FINDINGS: The frequency of TT, TC and CC genotypes was 88(73.9%), 31(26.1%) and (0.0%), respectively in case and it was 79(65.8%), 39(32.5%) and 2(1.7%), respectively in control (p=0.183). There was not a significant difference in genotype frequency between HCV patients and healthy control groups.CONCLUSION: The results of this study showed that there was no association between TNF-α gene 1031 polymorphism and chronic hepatitis C infection.SH Baradaran Ghavami,SR MohebbiH NaghoosiP AzimzadehE TahaeiS RomaniSH Almasi,A SanatiH MirtalbiBabol University of Medical Sciencesarticlegenotypechronic hepatitis cpolymorphismsingle nucleotidetumor necrosis factor alphageneticsMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 70-76 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	genotype chronic hepatitis c polymorphism single nucleotide tumor necrosis factor alpha genetics Medicine R Medicine (General) R5-920
spellingShingle	genotype chronic hepatitis c polymorphism single nucleotide tumor necrosis factor alpha genetics Medicine R Medicine (General) R5-920 SH Baradaran Ghavami, SR Mohebbi H Naghoosi P Azimzadeh E Tahaei S Romani SH Almasi, A Sanati H Mirtalbi Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
description	BACKGROUND AND OBJECTIVE: Infection with the hepatitis C virus (HCV) is leading cause of chronic liver disease. Cytokines play a key role in the modulation of immune response. Different single-nucleotide polymorphisms (SNPs) in TNF-Alpha promoter region have been identified. The aim of this study was to investigate the association of TNF-α gene 1031 polymorphism with chronic hepatitis C patients.METHODS: This study is a case-control study. Genomic DNA of 119 HCV patients infected and 120 healthy controls were extracted and their genotypes were determined by PCR (Polymerase Chain Reaction) and RFLP (Restriction Fragment Length Polymorphism). FINDINGS: The frequency of TT, TC and CC genotypes was 88(73.9%), 31(26.1%) and (0.0%), respectively in case and it was 79(65.8%), 39(32.5%) and 2(1.7%), respectively in control (p=0.183). There was not a significant difference in genotype frequency between HCV patients and healthy control groups.CONCLUSION: The results of this study showed that there was no association between TNF-α gene 1031 polymorphism and chronic hepatitis C infection.
format	article
author	SH Baradaran Ghavami, SR Mohebbi H Naghoosi P Azimzadeh E Tahaei S Romani SH Almasi, A Sanati H Mirtalbi
author_facet	SH Baradaran Ghavami, SR Mohebbi H Naghoosi P Azimzadeh E Tahaei S Romani SH Almasi, A Sanati H Mirtalbi
author_sort	SH Baradaran Ghavami,
title	Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
title_short	Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
title_full	Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
title_fullStr	Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
title_full_unstemmed	Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV
title_sort	association of tumor necrosis factor alpha (tnf-α)-1031 polymorphism with chronic infection of patients with hcv
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/fc91a6fcddb94fd9a8c793ae3cad2ef4
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Association of Tumor Necrosis Factor Alpha (TNF-α)-1031 Polymorphism with Chronic Infection of Patients with HCV

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