Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study...

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Autores principales:	Kyu Shik Mun, Kavisha Arora, Yunjie Huang, Fanmuyi Yang, Sunitha Yarlagadda, Yashaswini Ramananda, Maisam Abu-El-Haija, Joseph J. Palermo, Balamurugan N. Appakalai, Jaimie D. Nathan, Anjaparavanda P. Naren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc92be52f03349bab8a0daee67da4a27
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spelling	oai:doaj.org-article:fc92be52f03349bab8a0daee67da4a272021-12-02T15:36:20ZPatient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders10.1038/s41467-019-11178-w2041-1723https://doaj.org/article/fc92be52f03349bab8a0daee67da4a272019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11178-whttps://doaj.org/toc/2041-1723Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study how CF affects insulin secretion.Kyu Shik MunKavisha AroraYunjie HuangFanmuyi YangSunitha YarlagaddaYashaswini RamanandaMaisam Abu-El-HaijaJoseph J. PalermoBalamurugan N. AppakalaiJaimie D. NathanAnjaparavanda P. NarenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
description	Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study how CF affects insulin secretion.
format	article
author	Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren
author_facet	Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren
author_sort	Kyu Shik Mun
title	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_short	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_full	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_fullStr	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_full_unstemmed	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_sort	patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fc92be52f03349bab8a0daee67da4a27
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Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

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