Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study...

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Autores principales: Kyu Shik Mun, Kavisha Arora, Yunjie Huang, Fanmuyi Yang, Sunitha Yarlagadda, Yashaswini Ramananda, Maisam Abu-El-Haija, Joseph J. Palermo, Balamurugan N. Appakalai, Jaimie D. Nathan, Anjaparavanda P. Naren
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fc92be52f03349bab8a0daee67da4a27
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