Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoi...

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Autores principales: Jiang-Fei Li, Wei-Wei Xu, Rong-Hua Wang, Yue Li, Ge Yin, Mengchun Ye
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fc9481d72a2f432a9bd1db3333814250
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spelling oai:doaj.org-article:fc9481d72a2f432a9bd1db33338142502021-12-02T15:49:27ZConstruction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles10.1038/s41467-021-23371-x2041-1723https://doaj.org/article/fc9481d72a2f432a9bd1db33338142502021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23371-xhttps://doaj.org/toc/2041-1723Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.Jiang-Fei LiWei-Wei XuRong-Hua WangYue LiGe YinMengchun YeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiang-Fei Li
Wei-Wei Xu
Rong-Hua Wang
Yue Li
Ge Yin
Mengchun Ye
Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
description Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.
format article
author Jiang-Fei Li
Wei-Wei Xu
Rong-Hua Wang
Yue Li
Ge Yin
Mengchun Ye
author_facet Jiang-Fei Li
Wei-Wei Xu
Rong-Hua Wang
Yue Li
Ge Yin
Mengchun Ye
author_sort Jiang-Fei Li
title Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_short Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_full Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_fullStr Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_full_unstemmed Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_sort construction 7-membered ring via ni–al bimetal-enabled c–h cyclization for synthesis of tricyclic imidazoles
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fc9481d72a2f432a9bd1db3333814250
work_keys_str_mv AT jiangfeili construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
AT weiweixu construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
AT ronghuawang construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
AT yueli construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
AT geyin construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
AT mengchunye construction7memberedringvianialbimetalenabledchcyclizationforsynthesisoftricyclicimidazoles
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