Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia
Chronic lymphocytic leukemia has been studied using multiple levels of omics data. Here, the authors use exome sequencing, SNP, protein and gene expression data to identify distinct biologic tumor subtypes with heterogeneous prognostic impact after chemo- or immunochemotherapy.
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Nature Portfolio
2021
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oai:doaj.org-article:fc98052a777c445bb5de9e2a3b17c6072021-12-02T18:33:47ZMulti-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia10.1038/s41467-021-25403-y2041-1723https://doaj.org/article/fc98052a777c445bb5de9e2a3b17c6072021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25403-yhttps://doaj.org/toc/2041-1723Chronic lymphocytic leukemia has been studied using multiple levels of omics data. Here, the authors use exome sequencing, SNP, protein and gene expression data to identify distinct biologic tumor subtypes with heterogeneous prognostic impact after chemo- or immunochemotherapy.Johannes BloehdornAndrejs BraunAmaro Taylor-WeinerBilly Michael Chelliah JebarajSandra RobrechtJulia KrzykallaHeng PanAdam GizaGulnara AkylzhanovaKarlheinz HolzmannAnnika ScheffoldHarvey E. JohnstonRu-Fang YehTetyana KlymenkoEugen TauschBarbara EichhorstLars BullingerKirsten FischerMartin WeisserTadeusz RobakChristof SchneiderJohn GribbenLekh N. DahalMathew J. CarterOlivier ElementoDan A. LandauDonna S. NeubergMark S. CraggAxel BennerMichael HallekCatherine J. WuHartmut DöhnerStephan StilgenbauerDaniel MertensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Johannes Bloehdorn Andrejs Braun Amaro Taylor-Weiner Billy Michael Chelliah Jebaraj Sandra Robrecht Julia Krzykalla Heng Pan Adam Giza Gulnara Akylzhanova Karlheinz Holzmann Annika Scheffold Harvey E. Johnston Ru-Fang Yeh Tetyana Klymenko Eugen Tausch Barbara Eichhorst Lars Bullinger Kirsten Fischer Martin Weisser Tadeusz Robak Christof Schneider John Gribben Lekh N. Dahal Mathew J. Carter Olivier Elemento Dan A. Landau Donna S. Neuberg Mark S. Cragg Axel Benner Michael Hallek Catherine J. Wu Hartmut Döhner Stephan Stilgenbauer Daniel Mertens Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| description |
Chronic lymphocytic leukemia has been studied using multiple levels of omics data. Here, the authors use exome sequencing, SNP, protein and gene expression data to identify distinct biologic tumor subtypes with heterogeneous prognostic impact after chemo- or immunochemotherapy. |
| format |
article |
| author |
Johannes Bloehdorn Andrejs Braun Amaro Taylor-Weiner Billy Michael Chelliah Jebaraj Sandra Robrecht Julia Krzykalla Heng Pan Adam Giza Gulnara Akylzhanova Karlheinz Holzmann Annika Scheffold Harvey E. Johnston Ru-Fang Yeh Tetyana Klymenko Eugen Tausch Barbara Eichhorst Lars Bullinger Kirsten Fischer Martin Weisser Tadeusz Robak Christof Schneider John Gribben Lekh N. Dahal Mathew J. Carter Olivier Elemento Dan A. Landau Donna S. Neuberg Mark S. Cragg Axel Benner Michael Hallek Catherine J. Wu Hartmut Döhner Stephan Stilgenbauer Daniel Mertens |
| author_facet |
Johannes Bloehdorn Andrejs Braun Amaro Taylor-Weiner Billy Michael Chelliah Jebaraj Sandra Robrecht Julia Krzykalla Heng Pan Adam Giza Gulnara Akylzhanova Karlheinz Holzmann Annika Scheffold Harvey E. Johnston Ru-Fang Yeh Tetyana Klymenko Eugen Tausch Barbara Eichhorst Lars Bullinger Kirsten Fischer Martin Weisser Tadeusz Robak Christof Schneider John Gribben Lekh N. Dahal Mathew J. Carter Olivier Elemento Dan A. Landau Donna S. Neuberg Mark S. Cragg Axel Benner Michael Hallek Catherine J. Wu Hartmut Döhner Stephan Stilgenbauer Daniel Mertens |
| author_sort |
Johannes Bloehdorn |
| title |
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| title_short |
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| title_full |
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| title_fullStr |
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| title_full_unstemmed |
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| title_sort |
multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fc98052a777c445bb5de9e2a3b17c607 |
| work_keys_str_mv |
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| _version_ |
1718377957480726528 |