RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.

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Autores principales:	Timothy S. Catlett, Massimo M. Onesto, Alec J. McCann, Sarah K. Rempel, Jennifer Glass, David N. Franz, Timothy M. Gómez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc9b5914dcfa4ad4b2da1ea8ef8bcc7c
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spelling	oai:doaj.org-article:fc9b5914dcfa4ad4b2da1ea8ef8bcc7c2021-12-02T16:57:56ZRHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex10.1038/s41467-021-22770-42041-1723https://doaj.org/article/fc9b5914dcfa4ad4b2da1ea8ef8bcc7c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22770-4https://doaj.org/toc/2041-1723Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.Timothy S. CatlettMassimo M. OnestoAlec J. McCannSarah K. RempelJennifer GlassDavid N. FranzTimothy M. GómezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
description	Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.
format	article
author	Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez
author_facet	Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez
author_sort	Timothy S. Catlett
title	RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
title_short	RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
title_full	RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
title_fullStr	RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
title_full_unstemmed	RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
title_sort	rhoa signaling defects result in impaired axon guidance in ipsc-derived neurons from patients with tuberous sclerosis complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc9b5914dcfa4ad4b2da1ea8ef8bcc7c
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RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

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