A computational model of the epidermis with the deformable dermis and its application to skin diseases
Abstract The skin barrier is provided by the organized multi-layer structure of epidermal cells, which is dynamically maintained by a continuous supply of cells from the basal layer. The epidermal homeostasis can be disrupted by various skin diseases, which often cause morphological changes not only...
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Nature Portfolio
2021
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oai:doaj.org-article:fca2817c82154f88bad860b0c25001692021-12-02T17:12:17ZA computational model of the epidermis with the deformable dermis and its application to skin diseases10.1038/s41598-021-92540-12045-2322https://doaj.org/article/fca2817c82154f88bad860b0c25001692021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92540-1https://doaj.org/toc/2045-2322Abstract The skin barrier is provided by the organized multi-layer structure of epidermal cells, which is dynamically maintained by a continuous supply of cells from the basal layer. The epidermal homeostasis can be disrupted by various skin diseases, which often cause morphological changes not only in the epidermis but in the dermis. We present a three-dimensional agent-based computational model of the epidermis that takes into account the deformability of the dermis. Our model can produce a stable epidermal structure with well-organized layers. We show that its stability depends on the cell supply rate from the basal layer. Modeling the morphological change of the dermis also enables us to investigate how the stiffness of the dermis affects the structure and barrier functions of the epidermis. Besides, we show that our model can simulate the formation of a corn (clavus) by assuming hyperproliferation and rapid differentiation. We also provide experimental data for human corn, which supports the model assumptions and the simulation result.Kota OhnoYasuaki KobayashiMasaaki UesakaTakeshi GotodaMitsuhiro DendaHideyuki KosumiMika WatanabeKen NatsugaMasaharu NagayamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Kota Ohno Yasuaki Kobayashi Masaaki Uesaka Takeshi Gotoda Mitsuhiro Denda Hideyuki Kosumi Mika Watanabe Ken Natsuga Masaharu Nagayama A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| description |
Abstract The skin barrier is provided by the organized multi-layer structure of epidermal cells, which is dynamically maintained by a continuous supply of cells from the basal layer. The epidermal homeostasis can be disrupted by various skin diseases, which often cause morphological changes not only in the epidermis but in the dermis. We present a three-dimensional agent-based computational model of the epidermis that takes into account the deformability of the dermis. Our model can produce a stable epidermal structure with well-organized layers. We show that its stability depends on the cell supply rate from the basal layer. Modeling the morphological change of the dermis also enables us to investigate how the stiffness of the dermis affects the structure and barrier functions of the epidermis. Besides, we show that our model can simulate the formation of a corn (clavus) by assuming hyperproliferation and rapid differentiation. We also provide experimental data for human corn, which supports the model assumptions and the simulation result. |
| format |
article |
| author |
Kota Ohno Yasuaki Kobayashi Masaaki Uesaka Takeshi Gotoda Mitsuhiro Denda Hideyuki Kosumi Mika Watanabe Ken Natsuga Masaharu Nagayama |
| author_facet |
Kota Ohno Yasuaki Kobayashi Masaaki Uesaka Takeshi Gotoda Mitsuhiro Denda Hideyuki Kosumi Mika Watanabe Ken Natsuga Masaharu Nagayama |
| author_sort |
Kota Ohno |
| title |
A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| title_short |
A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| title_full |
A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| title_fullStr |
A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| title_full_unstemmed |
A computational model of the epidermis with the deformable dermis and its application to skin diseases |
| title_sort |
computational model of the epidermis with the deformable dermis and its application to skin diseases |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fca2817c82154f88bad860b0c2500169 |
| work_keys_str_mv |
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