Detecting structural heterogeneity in single-molecule localization microscopy data

Detecting structural heterogeneity in single-molecule localization microscopy data

Particle fusion can improve signal-to-noise ratio in single molecule localization microscopy, but is limited by structural heterogeneity. Here, the authors demonstrate an unsupervised classification method that differentiates structurally different DNA origami structures without prior knowledge.

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Autores principales: Teun A.P.M. Huijben, Hamidreza Heydarian, Alexander Auer, Florian Schueder, Ralf Jungmann, Sjoerd Stallinga, Bernd Rieger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/fca66482b21f4b50b38e7989abd579f0
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spelling oai:doaj.org-article:fca66482b21f4b50b38e7989abd579f02021-12-02T17:40:36ZDetecting structural heterogeneity in single-molecule localization microscopy data10.1038/s41467-021-24106-82041-1723https://doaj.org/article/fca66482b21f4b50b38e7989abd579f02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24106-8https://doaj.org/toc/2041-1723Particle fusion can improve signal-to-noise ratio in single molecule localization microscopy, but is limited by structural heterogeneity. Here, the authors demonstrate an unsupervised classification method that differentiates structurally different DNA origami structures without prior knowledge.Teun A.P.M. HuijbenHamidreza HeydarianAlexander AuerFlorian SchuederRalf JungmannSjoerd StallingaBernd RiegerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Teun A.P.M. Huijben
Hamidreza Heydarian
Alexander Auer
Florian Schueder
Ralf Jungmann
Sjoerd Stallinga
Bernd Rieger
Detecting structural heterogeneity in single-molecule localization microscopy data
description Particle fusion can improve signal-to-noise ratio in single molecule localization microscopy, but is limited by structural heterogeneity. Here, the authors demonstrate an unsupervised classification method that differentiates structurally different DNA origami structures without prior knowledge.
format article
author Teun A.P.M. Huijben
Hamidreza Heydarian
Alexander Auer
Florian Schueder
Ralf Jungmann
Sjoerd Stallinga
Bernd Rieger
author_facet Teun A.P.M. Huijben
Hamidreza Heydarian
Alexander Auer
Florian Schueder
Ralf Jungmann
Sjoerd Stallinga
Bernd Rieger
author_sort Teun A.P.M. Huijben
title Detecting structural heterogeneity in single-molecule localization microscopy data
title_short Detecting structural heterogeneity in single-molecule localization microscopy data
title_full Detecting structural heterogeneity in single-molecule localization microscopy data
title_fullStr Detecting structural heterogeneity in single-molecule localization microscopy data
title_full_unstemmed Detecting structural heterogeneity in single-molecule localization microscopy data
title_sort detecting structural heterogeneity in single-molecule localization microscopy data
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fca66482b21f4b50b38e7989abd579f0
work_keys_str_mv AT teunapmhuijben detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT hamidrezaheydarian detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT alexanderauer detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT florianschueder detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT ralfjungmann detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT sjoerdstallinga detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
AT berndrieger detectingstructuralheterogeneityinsinglemoleculelocalizationmicroscopydata
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