Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Cigarette smoke induces microRNA dysregulation in cancers. Here, the authors show that cigarette smoke promotes the maturation of oncogenic primary miR-25 due to METTL3 hypomethylation, and mature miR-25 suppresses PH domain leucine-rich repeat protein phosphatase 2, resulting in oncogenic AKT activ...

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Autores principales:	Jialiang Zhang, Ruihong Bai, Mei Li, Huilin Ye, Chen Wu, Chengfeng Wang, Shengping Li, Liping Tan, Dongmei Mai, Guolin Li, Ling Pan, Yanfen Zheng, Jiachun Su, Ying Ye, Zhiqiang Fu, Shangyou Zheng, Zhixiang Zuo, Zexian Liu, Qi Zhao, Xu Che, Dan Xie, Weihua Jia, Mu-Sheng Zeng, Wen Tan, Rufu Chen, Rui-Hua Xu, Jian Zheng, Dongxin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcab7ff250824f3f9ce4574f9ea642ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:fcab7ff250824f3f9ce4574f9ea642ed2021-12-02T17:32:54ZExcessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression10.1038/s41467-019-09712-x2041-1723https://doaj.org/article/fcab7ff250824f3f9ce4574f9ea642ed2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09712-xhttps://doaj.org/toc/2041-1723Cigarette smoke induces microRNA dysregulation in cancers. Here, the authors show that cigarette smoke promotes the maturation of oncogenic primary miR-25 due to METTL3 hypomethylation, and mature miR-25 suppresses PH domain leucine-rich repeat protein phosphatase 2, resulting in oncogenic AKT activation in pancreatic cancer.Jialiang ZhangRuihong BaiMei LiHuilin YeChen WuChengfeng WangShengping LiLiping TanDongmei MaiGuolin LiLing PanYanfen ZhengJiachun SuYing YeZhiqiang FuShangyou ZhengZhixiang ZuoZexian LiuQi ZhaoXu CheDan XieWeihua JiaMu-Sheng ZengWen TanRufu ChenRui-Hua XuJian ZhengDongxin LinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialiang Zhang Ruihong Bai Mei Li Huilin Ye Chen Wu Chengfeng Wang Shengping Li Liping Tan Dongmei Mai Guolin Li Ling Pan Yanfen Zheng Jiachun Su Ying Ye Zhiqiang Fu Shangyou Zheng Zhixiang Zuo Zexian Liu Qi Zhao Xu Che Dan Xie Weihua Jia Mu-Sheng Zeng Wen Tan Rufu Chen Rui-Hua Xu Jian Zheng Dongxin Lin Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
description	Cigarette smoke induces microRNA dysregulation in cancers. Here, the authors show that cigarette smoke promotes the maturation of oncogenic primary miR-25 due to METTL3 hypomethylation, and mature miR-25 suppresses PH domain leucine-rich repeat protein phosphatase 2, resulting in oncogenic AKT activation in pancreatic cancer.
format	article
author	Jialiang Zhang Ruihong Bai Mei Li Huilin Ye Chen Wu Chengfeng Wang Shengping Li Liping Tan Dongmei Mai Guolin Li Ling Pan Yanfen Zheng Jiachun Su Ying Ye Zhiqiang Fu Shangyou Zheng Zhixiang Zuo Zexian Liu Qi Zhao Xu Che Dan Xie Weihua Jia Mu-Sheng Zeng Wen Tan Rufu Chen Rui-Hua Xu Jian Zheng Dongxin Lin
author_facet	Jialiang Zhang Ruihong Bai Mei Li Huilin Ye Chen Wu Chengfeng Wang Shengping Li Liping Tan Dongmei Mai Guolin Li Ling Pan Yanfen Zheng Jiachun Su Ying Ye Zhiqiang Fu Shangyou Zheng Zhixiang Zuo Zexian Liu Qi Zhao Xu Che Dan Xie Weihua Jia Mu-Sheng Zeng Wen Tan Rufu Chen Rui-Hua Xu Jian Zheng Dongxin Lin
author_sort	Jialiang Zhang
title	Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
title_short	Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
title_full	Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
title_fullStr	Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
title_full_unstemmed	Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
title_sort	excessive mir-25-3p maturation via n 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fcab7ff250824f3f9ce4574f9ea642ed
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Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

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