Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings

Antoni Sicras-Mainar1, Ruth Navarro-Artieda2, Javier Rejas-Guti&eacute;rrez3, Milagrosa Blanca-Tamayo41Planning Management, Badalona Serveis Assistencials S.A., Badalona, Barcelona, Spain; 2Medical Documentation Service, Hospital Germans Tr&iacute;as i Pujol, Badalona, Barcelona, Spa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antoni Sicras-Mainar, Ruth Navarro-Artieda, Javier Rejas-Guti&eacute;rrez, Milagrosa Blanca-Tamayo
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fcae4561274f46e7b28e913bdca832b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fcae4561274f46e7b28e913bdca832b5
record_format	dspace
spelling	oai:doaj.org-article:fcae4561274f46e7b28e913bdca832b52021-12-02T04:08:43ZRelationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings1176-63281178-2021https://doaj.org/article/fcae4561274f46e7b28e913bdca832b52008-03-01T00:00:00Zhttp://www.dovepress.com/relationship-between-obesity-and-antipsychotic-drug-use-in-the-adult-p-a987https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Antoni Sicras-Mainar1, Ruth Navarro-Artieda2, Javier Rejas-Guti&eacute;rrez3, Milagrosa Blanca-Tamayo41Planning Management, Badalona Serveis Assistencials S.A., Badalona, Barcelona, Spain; 2Medical Documentation Service, Hospital Germans Tr&iacute;as i Pujol, Badalona, Barcelona, Spain; 3Health Outcomes Research Derpartment, Medical Unit, Pfizer Spain, Alcobendas, Madrid, Spain; 4Department of Psychiatry, Badalona Serveis Assistencials S.A., Badalona, Barcelona, SpainObjective: To describe the association between obesity and the use of antipsychotic drugs (APDs) in adult outpatients followed-up on in five Primary Care settings.Methods: A longitudinal, retrospective design study carried out between July 2004 and June 2005, in patients who were included in a claim database and for whom an APD treatment had been registered. A body mass index (BMI) &lt;30 kg/m2 was defined as obesity. The main measurements were: use of APDs, demographics, medical background and co-morbidities, and clinical parameters. Logistic regression analysis and ANCOVA with Bonferroni adjustment were applied to correct the model.Results: A total of 42,437 subjects (mean age: 50.8 (18.4) years; women: 54.5%; obesity: 27.3% [95% confidence intervals (CI), 26.9%&ndash;27.7%]) were analyzed. A total of 1.3% of the patients were receiving APDs, without statistical differences in distribution by type of drug (typical: 48.8%; atypical: 51.2%). Obesity was associated with the use of APDs [OR = 1.5 (CI: 1.3&ndash;1.8)], hypertension [OR = 2.4 (CI: 2.2&ndash;2.5)], diabetes [OR = 1.4 (CI: 1.3&ndash;1.5)] and dyslipidemia [OR = 1.3 (CI: 1.2&ndash;1.4)], p &lt; 0.0001 in all cases. BMI was significantly higher in subjects on APDs; 28.8 vs. 27.3 kg/m2, p = 0.002, and remained higher after adjusting by age and sex (mean difference 0.4 (CI: 0.1&ndash;0.7), p &lt; 0.01). After adjusting by age, sex and the Charlson index, obese subjects generated higher average annual total costs than nonobese subjects; 811 (CI: 787&ndash;835) vs. 694 (CI: 679&ndash;709), respectively, p &lt; 0.001.Conclusions: Obesity was associated with the use of APDs, regardless of the type of drug, and with the presence of hypertension, diabetes and dyslipidemia. Obesity was also associated with substantially higher health care costs.Keywords: Obesity, claim database, retrospective study, antipsychotic use, Primary Care setting, resources utilization, health care costs Antoni Sicras-MainarRuth Navarro-ArtiedaJavier Rejas-Guti&eacute;rrezMilagrosa Blanca-TamayoDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 219-226 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Antoni Sicras-Mainar Ruth Navarro-Artieda Javier Rejas-Guti&eacute;rrez Milagrosa Blanca-Tamayo Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
description	Antoni Sicras-Mainar1, Ruth Navarro-Artieda2, Javier Rejas-Guti&eacute;rrez3, Milagrosa Blanca-Tamayo41Planning Management, Badalona Serveis Assistencials S.A., Badalona, Barcelona, Spain; 2Medical Documentation Service, Hospital Germans Tr&iacute;as i Pujol, Badalona, Barcelona, Spain; 3Health Outcomes Research Derpartment, Medical Unit, Pfizer Spain, Alcobendas, Madrid, Spain; 4Department of Psychiatry, Badalona Serveis Assistencials S.A., Badalona, Barcelona, SpainObjective: To describe the association between obesity and the use of antipsychotic drugs (APDs) in adult outpatients followed-up on in five Primary Care settings.Methods: A longitudinal, retrospective design study carried out between July 2004 and June 2005, in patients who were included in a claim database and for whom an APD treatment had been registered. A body mass index (BMI) &lt;30 kg/m2 was defined as obesity. The main measurements were: use of APDs, demographics, medical background and co-morbidities, and clinical parameters. Logistic regression analysis and ANCOVA with Bonferroni adjustment were applied to correct the model.Results: A total of 42,437 subjects (mean age: 50.8 (18.4) years; women: 54.5%; obesity: 27.3% [95% confidence intervals (CI), 26.9%&ndash;27.7%]) were analyzed. A total of 1.3% of the patients were receiving APDs, without statistical differences in distribution by type of drug (typical: 48.8%; atypical: 51.2%). Obesity was associated with the use of APDs [OR = 1.5 (CI: 1.3&ndash;1.8)], hypertension [OR = 2.4 (CI: 2.2&ndash;2.5)], diabetes [OR = 1.4 (CI: 1.3&ndash;1.5)] and dyslipidemia [OR = 1.3 (CI: 1.2&ndash;1.4)], p &lt; 0.0001 in all cases. BMI was significantly higher in subjects on APDs; 28.8 vs. 27.3 kg/m2, p = 0.002, and remained higher after adjusting by age and sex (mean difference 0.4 (CI: 0.1&ndash;0.7), p &lt; 0.01). After adjusting by age, sex and the Charlson index, obese subjects generated higher average annual total costs than nonobese subjects; 811 (CI: 787&ndash;835) vs. 694 (CI: 679&ndash;709), respectively, p &lt; 0.001.Conclusions: Obesity was associated with the use of APDs, regardless of the type of drug, and with the presence of hypertension, diabetes and dyslipidemia. Obesity was also associated with substantially higher health care costs.Keywords: Obesity, claim database, retrospective study, antipsychotic use, Primary Care setting, resources utilization, health care costs
format	article
author	Antoni Sicras-Mainar Ruth Navarro-Artieda Javier Rejas-Guti&eacute;rrez Milagrosa Blanca-Tamayo
author_facet	Antoni Sicras-Mainar Ruth Navarro-Artieda Javier Rejas-Guti&eacute;rrez Milagrosa Blanca-Tamayo
author_sort	Antoni Sicras-Mainar
title	Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
title_short	Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
title_full	Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
title_fullStr	Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
title_full_unstemmed	Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings
title_sort	relationship between obesity and antipsychotic drug use in the adult population: a longitudinal, retrospective claim database study in primary care settings
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/fcae4561274f46e7b28e913bdca832b5
work_keys_str_mv	AT antonisicrasmainar relationshipbetweenobesityandantipsychoticdruguseintheadultpopulationalongitudinalretrospectiveclaimdatabasestudyinprimarycaresettings AT ruthnavarroartieda relationshipbetweenobesityandantipsychoticdruguseintheadultpopulationalongitudinalretrospectiveclaimdatabasestudyinprimarycaresettings AT javierrejasgutiampeacuterrez relationshipbetweenobesityandantipsychoticdruguseintheadultpopulationalongitudinalretrospectiveclaimdatabasestudyinprimarycaresettings AT milagrosablancatamayo relationshipbetweenobesityandantipsychoticdruguseintheadultpopulationalongitudinalretrospectiveclaimdatabasestudyinprimarycaresettings
_version_	1718401468087664640

Relationship between obesity and antipsychotic drug use in the adult population: A longitudinal, retrospective claim database study in Primary Care settings

Ejemplares similares