Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice

Renal dysfunction is often associated with the inflammatory cascade, leading to non-reversible nephrofibrosis. Gene therapy has the ability to treat the pathology. However, the difficulty in introducing genes into the kidney, via either viral vectors or plasmid DNA (pDNA), has hampered its extensive...

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Bibliographic Details
Main Authors: Natsuko Oyama, Maho Kawaguchi, Keiji Itaka, Shigeru Kawakami
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/fcae87e9a1ee4988aeb9d5cb3859540f
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