Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam

Pneumonia is a major cause of morbidity and mortality in children globally. Lactate, a product of anaerobic cellular metabolism, has been used as an indicator of poor tissue oxygenation and cellular hypoxia. Our objective was to determine whether serum lactate concentration at hospital admission pre...

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Autores principales:	Son Bui-Binh-Bao, Trang Nguyen-Thi-My, Anh Nguyen-Duy-Nam, Nguyen Thi Kim Hoa, Dung Pham-Van
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/fcaf686e7d134fdfb0a85fe737a33f90
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spelling	oai:doaj.org-article:fcaf686e7d134fdfb0a85fe737a33f902021-12-01T02:03:29ZIs Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam2333-794X10.1177/2333794X211060806https://doaj.org/article/fcaf686e7d134fdfb0a85fe737a33f902021-11-01T00:00:00Zhttps://doi.org/10.1177/2333794X211060806https://doaj.org/toc/2333-794XPneumonia is a major cause of morbidity and mortality in children globally. Lactate, a product of anaerobic cellular metabolism, has been used as an indicator of poor tissue oxygenation and cellular hypoxia. Our objective was to determine whether serum lactate concentration at hospital admission predicted mortality in children aged 2 months to 5 years with pneumonia. Two hundred and eighty-one pediatric patients admitted to the Department of Pediatrics of a provincial hospital with WHO-defined pneumonia and severe pneumonia were included; of whom, 8 died during hospital stay. The median serum lactate concentration was 4.8 mmol/l (IQR 2.6-6.9) among children who died and 3.6 mmol/l (IQR 2.8-4.3) among children who survived ( P > .05); 4.1 mmol/l (IQR 2.7-4.7) among children with severe pneumonia and 3.5 mmol/l (IQR 2.8-4.3) among children with pneumonia ( P > .05). Serum lactate concentration had a low value in predicting pneumonia-related mortality (AUC 0.68, 95% CI 0.62-0.73); and the concentration cut-off of >4.06 mmol/l had the best sensitivity and specificity (75% and 68.9%, respectively) with a 2.4-fold risk of death (LR+ 2.4; 95% CI 1.6-3.7). Although hyperlactatemia was associated with severity and mortality in children 2 months to 5 years of age with pneumonia, its benefit was unclear.Son Bui-Binh-BaoTrang Nguyen-Thi-MyAnh Nguyen-Duy-NamNguyen Thi Kim HoaDung Pham-VanSAGE PublishingarticlePediatricsRJ1-570ENGlobal Pediatric Health, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pediatrics RJ1-570
spellingShingle	Pediatrics RJ1-570 Son Bui-Binh-Bao Trang Nguyen-Thi-My Anh Nguyen-Duy-Nam Nguyen Thi Kim Hoa Dung Pham-Van Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
description	Pneumonia is a major cause of morbidity and mortality in children globally. Lactate, a product of anaerobic cellular metabolism, has been used as an indicator of poor tissue oxygenation and cellular hypoxia. Our objective was to determine whether serum lactate concentration at hospital admission predicted mortality in children aged 2 months to 5 years with pneumonia. Two hundred and eighty-one pediatric patients admitted to the Department of Pediatrics of a provincial hospital with WHO-defined pneumonia and severe pneumonia were included; of whom, 8 died during hospital stay. The median serum lactate concentration was 4.8 mmol/l (IQR 2.6-6.9) among children who died and 3.6 mmol/l (IQR 2.8-4.3) among children who survived ( P > .05); 4.1 mmol/l (IQR 2.7-4.7) among children with severe pneumonia and 3.5 mmol/l (IQR 2.8-4.3) among children with pneumonia ( P > .05). Serum lactate concentration had a low value in predicting pneumonia-related mortality (AUC 0.68, 95% CI 0.62-0.73); and the concentration cut-off of >4.06 mmol/l had the best sensitivity and specificity (75% and 68.9%, respectively) with a 2.4-fold risk of death (LR+ 2.4; 95% CI 1.6-3.7). Although hyperlactatemia was associated with severity and mortality in children 2 months to 5 years of age with pneumonia, its benefit was unclear.
format	article
author	Son Bui-Binh-Bao Trang Nguyen-Thi-My Anh Nguyen-Duy-Nam Nguyen Thi Kim Hoa Dung Pham-Van
author_facet	Son Bui-Binh-Bao Trang Nguyen-Thi-My Anh Nguyen-Duy-Nam Nguyen Thi Kim Hoa Dung Pham-Van
author_sort	Son Bui-Binh-Bao
title	Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
title_short	Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
title_full	Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
title_fullStr	Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
title_full_unstemmed	Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam
title_sort	is serum lactate a good predictor of mortality in children aged 2 months to 5 years with pneumonia in central vietnam
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/fcaf686e7d134fdfb0a85fe737a33f90
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Is Serum Lactate a Good Predictor of Mortality in Children Aged 2 Months to 5 Years With Pneumonia in Central Vietnam

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