Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast.

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Autores principales:	Gregory T. Booth, Pabitra K. Parua, Miriam Sansó, Robert P. Fisher, John T. Lis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcb0fae25f044fe193746041c137258a
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spelling	oai:doaj.org-article:fcb0fae25f044fe193746041c137258a2021-12-02T17:33:03ZCdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast10.1038/s41467-018-03006-42041-1723https://doaj.org/article/fcb0fae25f044fe193746041c137258a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03006-4https://doaj.org/toc/2041-1723While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast.Gregory T. BoothPabitra K. ParuaMiriam SansóRobert P. FisherJohn T. LisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
description	While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast.
format	article
author	Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis
author_facet	Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis
author_sort	Gregory T. Booth
title	Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
title_short	Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
title_full	Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
title_fullStr	Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
title_full_unstemmed	Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
title_sort	cdk9 regulates a promoter-proximal checkpoint to modulate rna polymerase ii elongation rate in fission yeast
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fcb0fae25f044fe193746041c137258a
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Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

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