Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.

<h4>Background</h4>Preeclampsia remains a leading cause of maternal mortality and preterm delivery. Both preeclampsia and bronchopulmonary dysplasia (BPD) of prematurity are associated with impaired angiogenesis. However, the relationship between maternal preeclampsia and BPD remains con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting-An Yen, Hwai-I Yang, Wu-Shiun Hsieh, Hung-Chieh Chou, Chien-Yi Chen, Kuo-Inn Tsou, Po-Nien Tsao, Taiwan Premature Infant Developmental Collaborative Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fcb24be688e44198849ddbb4ce6cebe2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fcb24be688e44198849ddbb4ce6cebe2
record_format	dspace
spelling	oai:doaj.org-article:fcb24be688e44198849ddbb4ce6cebe22021-11-18T08:54:21ZPreeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.1932-620310.1371/journal.pone.0075168https://doaj.org/article/fcb24be688e44198849ddbb4ce6cebe22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24073247/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Preeclampsia remains a leading cause of maternal mortality and preterm delivery. Both preeclampsia and bronchopulmonary dysplasia (BPD) of prematurity are associated with impaired angiogenesis. However, the relationship between maternal preeclampsia and BPD remains controversial. This study aims to test whether or not preeclampsia is associated with development of BPD in a cohort of premature infants.<h4>Materials and methods</h4>We conducted a retrospective cohort study assessing the association between preeclampsia and the risk of developing BPD in very-low-birth-weight (VLBW) infants registered in the Premature Baby Foundation of Taiwan from 1997 through 2006. All 21 neonatal departments in Taiwan participated in the data collection. A total of 8,653 VLBW infants were registered in the database. The exclusion criteria included congenital anomalies, chromosome anomalies, infants that died before 36 weeks post-conceptual (PCA), and those whose BPD status were unavailable. BPD was defined as oxygen dependence at 36 weeks postmenstrual age. The association between maternal preeclampsia and BPD was assessed using a multivariate-adjusted logistic regression model.<h4>Results</h4>In the end, a total of 5,753 cases were enrolled in this study. The incidence of preeclampsia was 14.7% (n=847) and the overall incidence of BPD was 34.9%. Infants with maternal preeclampsia had a higher gestational age, higher incidence of cesarean section and being small for their gestational age, lower incidence of respiratory distress syndrome, patent ductus arteriosus, and sepsis. BPD occurred significantly less frequently in the maternal preeclampsia group (24.1% vs. 36.7%; adjusted odds ratio: 0.78; 95% confidence interval, 0.62-0.98). Subgroup analysis showed that the association between preeclampsia and BPD was significant only in those VLBW infants with a gestational age between 31-34 weeks.<h4>Conclusion</h4>This data supports the association between fetal exposure to maternal preeclampsia and a reduced risk of BPD in relatively mature VLBW infants.Ting-An YenHwai-I YangWu-Shiun HsiehWu-Shiun HsiehHung-Chieh ChouChien-Yi ChenKuo-Inn TsouPo-Nien TsaoTaiwan Premature Infant Developmental Collaborative Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75168 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting-An Yen Hwai-I Yang Wu-Shiun Hsieh Wu-Shiun Hsieh Hung-Chieh Chou Chien-Yi Chen Kuo-Inn Tsou Po-Nien Tsao Taiwan Premature Infant Developmental Collaborative Study Group Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
description	<h4>Background</h4>Preeclampsia remains a leading cause of maternal mortality and preterm delivery. Both preeclampsia and bronchopulmonary dysplasia (BPD) of prematurity are associated with impaired angiogenesis. However, the relationship between maternal preeclampsia and BPD remains controversial. This study aims to test whether or not preeclampsia is associated with development of BPD in a cohort of premature infants.<h4>Materials and methods</h4>We conducted a retrospective cohort study assessing the association between preeclampsia and the risk of developing BPD in very-low-birth-weight (VLBW) infants registered in the Premature Baby Foundation of Taiwan from 1997 through 2006. All 21 neonatal departments in Taiwan participated in the data collection. A total of 8,653 VLBW infants were registered in the database. The exclusion criteria included congenital anomalies, chromosome anomalies, infants that died before 36 weeks post-conceptual (PCA), and those whose BPD status were unavailable. BPD was defined as oxygen dependence at 36 weeks postmenstrual age. The association between maternal preeclampsia and BPD was assessed using a multivariate-adjusted logistic regression model.<h4>Results</h4>In the end, a total of 5,753 cases were enrolled in this study. The incidence of preeclampsia was 14.7% (n=847) and the overall incidence of BPD was 34.9%. Infants with maternal preeclampsia had a higher gestational age, higher incidence of cesarean section and being small for their gestational age, lower incidence of respiratory distress syndrome, patent ductus arteriosus, and sepsis. BPD occurred significantly less frequently in the maternal preeclampsia group (24.1% vs. 36.7%; adjusted odds ratio: 0.78; 95% confidence interval, 0.62-0.98). Subgroup analysis showed that the association between preeclampsia and BPD was significant only in those VLBW infants with a gestational age between 31-34 weeks.<h4>Conclusion</h4>This data supports the association between fetal exposure to maternal preeclampsia and a reduced risk of BPD in relatively mature VLBW infants.
format	article
author	Ting-An Yen Hwai-I Yang Wu-Shiun Hsieh Wu-Shiun Hsieh Hung-Chieh Chou Chien-Yi Chen Kuo-Inn Tsou Po-Nien Tsao Taiwan Premature Infant Developmental Collaborative Study Group
author_facet	Ting-An Yen Hwai-I Yang Wu-Shiun Hsieh Wu-Shiun Hsieh Hung-Chieh Chou Chien-Yi Chen Kuo-Inn Tsou Po-Nien Tsao Taiwan Premature Infant Developmental Collaborative Study Group
author_sort	Ting-An Yen
title	Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
title_short	Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
title_full	Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
title_fullStr	Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
title_full_unstemmed	Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.
title_sort	preeclampsia and the risk of bronchopulmonary dysplasia in vlbw infants: a population based study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fcb24be688e44198849ddbb4ce6cebe2
work_keys_str_mv	AT tinganyen preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT hwaiiyang preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT wushiunhsieh preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT wushiunhsieh preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT hungchiehchou preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT chienyichen preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT kuoinntsou preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT ponientsao preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy AT taiwanprematureinfantdevelopmentalcollaborativestudygroup preeclampsiaandtheriskofbronchopulmonarydysplasiainvlbwinfantsapopulationbasedstudy
_version_	1718421241173377024

Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study.

Ejemplares similares