Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology

Airway wall remodeling is a pathology occurring in chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and fibrosis. In 2017, the American Thoracic Society released a research statement highlighting the gaps in knowledge and understanding of airway wall remode...

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Autores principales:	Lei Fang, Michael Roth
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	airway wall remodeling asthma epigenetic bronchial epithelium cell-cell interaction inflammation Medicine R
Acceso en línea:	https://doaj.org/article/fcb4bc148b9c48b190246a145da232d4
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spelling	oai:doaj.org-article:fcb4bc148b9c48b190246a145da232d42021-11-25T18:08:11ZAirway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology10.3390/jpm111112292075-4426https://doaj.org/article/fcb4bc148b9c48b190246a145da232d42021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1229https://doaj.org/toc/2075-4426Airway wall remodeling is a pathology occurring in chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and fibrosis. In 2017, the American Thoracic Society released a research statement highlighting the gaps in knowledge and understanding of airway wall remodeling. The four major challenges addressed in this statement were: (i) the lack of consensus to define “airway wall remodeling” in different diseases, (ii) methodologic limitations and inappropriate models, (iii) the lack of anti-remodeling therapies, and (iv) the difficulty to define endpoints and outcomes in relevant studies. This review focuses on the importance of cell-cell interaction, especially the bronchial epithelium, in asthma-associated airway wall remodeling. The pathology of “airway wall remodeling” summarizes all structural changes of the airway wall without differentiating between different pheno- or endo-types of asthma. Indicators of airway wall remodeling have been reported in childhood asthma in the absence of any sign of inflammation; thus, the initiation event remains unknown. Recent studies have implied that the interaction between the epithelium with immune cells and sub-epithelial mesenchymal cells is modified in asthma by a yet unknown epigenetic mechanism during early childhood.Lei FangMichael RothMDPI AGarticleairway wall remodelingasthmaepigeneticbronchial epitheliumcell-cell interactioninflammationMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1229, p 1229 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	airway wall remodeling asthma epigenetic bronchial epithelium cell-cell interaction inflammation Medicine R
spellingShingle	airway wall remodeling asthma epigenetic bronchial epithelium cell-cell interaction inflammation Medicine R Lei Fang Michael Roth Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
description	Airway wall remodeling is a pathology occurring in chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and fibrosis. In 2017, the American Thoracic Society released a research statement highlighting the gaps in knowledge and understanding of airway wall remodeling. The four major challenges addressed in this statement were: (i) the lack of consensus to define “airway wall remodeling” in different diseases, (ii) methodologic limitations and inappropriate models, (iii) the lack of anti-remodeling therapies, and (iv) the difficulty to define endpoints and outcomes in relevant studies. This review focuses on the importance of cell-cell interaction, especially the bronchial epithelium, in asthma-associated airway wall remodeling. The pathology of “airway wall remodeling” summarizes all structural changes of the airway wall without differentiating between different pheno- or endo-types of asthma. Indicators of airway wall remodeling have been reported in childhood asthma in the absence of any sign of inflammation; thus, the initiation event remains unknown. Recent studies have implied that the interaction between the epithelium with immune cells and sub-epithelial mesenchymal cells is modified in asthma by a yet unknown epigenetic mechanism during early childhood.
format	article
author	Lei Fang Michael Roth
author_facet	Lei Fang Michael Roth
author_sort	Lei Fang
title	Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
title_short	Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
title_full	Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
title_fullStr	Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
title_full_unstemmed	Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology
title_sort	airway wall remodeling in childhood asthma—a personalized perspective from cell type-specific biology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fcb4bc148b9c48b190246a145da232d4
work_keys_str_mv	AT leifang airwaywallremodelinginchildhoodasthmaapersonalizedperspectivefromcelltypespecificbiology AT michaelroth airwaywallremodelinginchildhoodasthmaapersonalizedperspectivefromcelltypespecificbiology
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Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology

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