Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molec...

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Autores principales:	Yin Liang, Zhang Mingxue, He Tiangeng
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	alr2 compound synthesis hybrid diabetes cataract Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/fcbbfce5d0d446fd9f55f238464cbc99
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id	oai:doaj.org-article:fcbbfce5d0d446fd9f55f238464cbc99
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spelling	oai:doaj.org-article:fcbbfce5d0d446fd9f55f238464cbc992021-12-05T14:10:50ZDesign and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase2191-019710.1515/hc-2020-0124https://doaj.org/article/fcbbfce5d0d446fd9f55f238464cbc992021-09-01T00:00:00Zhttps://doi.org/10.1515/hc-2020-0124https://doaj.org/toc/2191-0197In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molecules significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound 7b showed activity comparable to sorbinil as standard. In Wistar rats, compound 7b improved the insulin level and body weight of the experimental animal together with a reduction in the glucose output. Compound 7b showed a significant reduction in the expression of ALR2 in rat lenses in western blot analysis.Yin LiangZhang MingxueHe TiangengDe Gruyterarticlealr2compound synthesishybriddiabetescataractOrganic chemistryQD241-441ENHeterocyclic Communications, Vol 27, Iss 1, Pp 63-70 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alr2 compound synthesis hybrid diabetes cataract Organic chemistry QD241-441
spellingShingle	alr2 compound synthesis hybrid diabetes cataract Organic chemistry QD241-441 Yin Liang Zhang Mingxue He Tiangeng Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
description	In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molecules significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound 7b showed activity comparable to sorbinil as standard. In Wistar rats, compound 7b improved the insulin level and body weight of the experimental animal together with a reduction in the glucose output. Compound 7b showed a significant reduction in the expression of ALR2 in rat lenses in western blot analysis.
format	article
author	Yin Liang Zhang Mingxue He Tiangeng
author_facet	Yin Liang Zhang Mingxue He Tiangeng
author_sort	Yin Liang
title	Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
title_short	Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
title_full	Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
title_fullStr	Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
title_full_unstemmed	Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
title_sort	design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in wistar rats via inhibition of aldose reductase
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/fcbbfce5d0d446fd9f55f238464cbc99
work_keys_str_mv	AT yinliang designanddevelopmentofnovelthiazolesulfonamidederivativesasaprotectiveagentagainstdiabeticcataractinwistarratsviainhibitionofaldosereductase AT zhangmingxue designanddevelopmentofnovelthiazolesulfonamidederivativesasaprotectiveagentagainstdiabeticcataractinwistarratsviainhibitionofaldosereductase AT hetiangeng designanddevelopmentofnovelthiazolesulfonamidederivativesasaprotectiveagentagainstdiabeticcataractinwistarratsviainhibitionofaldosereductase
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Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

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