Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity

Qiankun Chen,1 Ji Liu2 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; 2Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Aim: The aim of this study was to prepare transfer...

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Autores principales:	Chen Q, Liu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	transferrin folic acid liposomes bufalin in vivo imaging anti-tumor activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fcbda67b6779471d9a4e4e075b6deab0
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spelling	oai:doaj.org-article:fcbda67b6779471d9a4e4e075b6deab02021-12-02T07:32:25ZTransferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity1178-2013https://doaj.org/article/fcbda67b6779471d9a4e4e075b6deab02018-10-01T00:00:00Zhttps://www.dovepress.com/transferrin-and-folic-acid-co-modified-bufalin-loaded-nanoliposomes-pr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qiankun Chen,1 Ji Liu2 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; 2Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Aim: The aim of this study was to prepare transferrin (Tf) and folic acid (FA) co-modified bufalin (BF) liposomes for lung cancer treatment.Method: In this study, (FA+Tf) BF-LPs were prepared using the high-pressure homogenization method.Results: The EE% and DL% of prepared LPs were 82.3% and 10.7%, respectively, and the mean diameter was 120.4 nm from three batches. In vitro release showed that the release of BF from (FA+Tf) BF-LPs was slow with burst effects at an early stage. In vitro cytotoxicity assay showed that (FA+Tf) BF-LPs had a superior antiproliferative effect on A549 cells. An in vivo imaging study indicated that (FA+Tf) BF-LPs had obvious targeting characteristics on subcutaneous tumor, with the potential to actively deliver drugs to tumor tissues. In terms of the in vivo antitumor activity, (FA+Tf) BF-LPs treated mice showed a significantly suppressed tumor growth and no systemic toxicity in the body.Conclusion: Through this study, it was found that the Tf and FA co-modified BF could be a very promising lung target preparation. Keywords: transferrin, folic acid, liposomes, bufalin, in vivo imaging, antitumor activityChen QLiu JDove Medical Pressarticletransferrinfolic acidliposomesbufalinin vivo imaginganti-tumor activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6009-6018 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	transferrin folic acid liposomes bufalin in vivo imaging anti-tumor activity Medicine (General) R5-920
spellingShingle	transferrin folic acid liposomes bufalin in vivo imaging anti-tumor activity Medicine (General) R5-920 Chen Q Liu J Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
description	Qiankun Chen,1 Ji Liu2 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; 2Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Aim: The aim of this study was to prepare transferrin (Tf) and folic acid (FA) co-modified bufalin (BF) liposomes for lung cancer treatment.Method: In this study, (FA+Tf) BF-LPs were prepared using the high-pressure homogenization method.Results: The EE% and DL% of prepared LPs were 82.3% and 10.7%, respectively, and the mean diameter was 120.4 nm from three batches. In vitro release showed that the release of BF from (FA+Tf) BF-LPs was slow with burst effects at an early stage. In vitro cytotoxicity assay showed that (FA+Tf) BF-LPs had a superior antiproliferative effect on A549 cells. An in vivo imaging study indicated that (FA+Tf) BF-LPs had obvious targeting characteristics on subcutaneous tumor, with the potential to actively deliver drugs to tumor tissues. In terms of the in vivo antitumor activity, (FA+Tf) BF-LPs treated mice showed a significantly suppressed tumor growth and no systemic toxicity in the body.Conclusion: Through this study, it was found that the Tf and FA co-modified BF could be a very promising lung target preparation. Keywords: transferrin, folic acid, liposomes, bufalin, in vivo imaging, antitumor activity
format	article
author	Chen Q Liu J
author_facet	Chen Q Liu J
author_sort	Chen Q
title	Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
title_short	Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
title_full	Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
title_fullStr	Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
title_full_unstemmed	Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
title_sort	transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fcbda67b6779471d9a4e4e075b6deab0
work_keys_str_mv	AT chenq transferrinandfolicacidcomodifiedbufalinloadednanoliposomespreparationcharacterizationandapplicationinanticanceractivity AT liuj transferrinandfolicacidcomodifiedbufalinloadednanoliposomespreparationcharacterizationandapplicationinanticanceractivity
_version_	1718399378667864064

Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity

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