Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

Mouse models of CDKL5 deficiency disorder (CDD) recapitulate multiple clinical symptoms of CDD, such as intellectual disability and autism. Here, the authors show that selective loss of CDKL5 from GABAergic neurons leads to social deficits and stereotypic behaviors, which can be ameliorated through...

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Autores principales:	Sheng Tang, Barbara Terzic, I-Ting Judy Wang, Nicolas Sarmiento, Katherine Sizov, Yue Cui, Hajime Takano, Eric D. Marsh, Zhaolan Zhou, Douglas A. Coulter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcc09e9d517f46139fc63936735506c3
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spelling	oai:doaj.org-article:fcc09e9d517f46139fc63936735506c32021-12-02T14:35:56ZAltered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder10.1038/s41467-019-10689-w2041-1723https://doaj.org/article/fcc09e9d517f46139fc63936735506c32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10689-whttps://doaj.org/toc/2041-1723Mouse models of CDKL5 deficiency disorder (CDD) recapitulate multiple clinical symptoms of CDD, such as intellectual disability and autism. Here, the authors show that selective loss of CDKL5 from GABAergic neurons leads to social deficits and stereotypic behaviors, which can be ameliorated through inhibition of NMDAR signaling.Sheng TangBarbara TerzicI-Ting Judy WangNicolas SarmientoKatherine SizovYue CuiHajime TakanoEric D. MarshZhaolan ZhouDouglas A. CoulterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheng Tang Barbara Terzic I-Ting Judy Wang Nicolas Sarmiento Katherine Sizov Yue Cui Hajime Takano Eric D. Marsh Zhaolan Zhou Douglas A. Coulter Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
description	Mouse models of CDKL5 deficiency disorder (CDD) recapitulate multiple clinical symptoms of CDD, such as intellectual disability and autism. Here, the authors show that selective loss of CDKL5 from GABAergic neurons leads to social deficits and stereotypic behaviors, which can be ameliorated through inhibition of NMDAR signaling.
format	article
author	Sheng Tang Barbara Terzic I-Ting Judy Wang Nicolas Sarmiento Katherine Sizov Yue Cui Hajime Takano Eric D. Marsh Zhaolan Zhou Douglas A. Coulter
author_facet	Sheng Tang Barbara Terzic I-Ting Judy Wang Nicolas Sarmiento Katherine Sizov Yue Cui Hajime Takano Eric D. Marsh Zhaolan Zhou Douglas A. Coulter
author_sort	Sheng Tang
title	Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
title_short	Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
title_full	Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
title_fullStr	Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
title_full_unstemmed	Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
title_sort	altered nmdar signaling underlies autistic-like features in mouse models of cdkl5 deficiency disorder
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fcc09e9d517f46139fc63936735506c3
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Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

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