Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

Mouse models of CDKL5 deficiency disorder (CDD) recapitulate multiple clinical symptoms of CDD, such as intellectual disability and autism. Here, the authors show that selective loss of CDKL5 from GABAergic neurons leads to social deficits and stereotypic behaviors, which can be ameliorated through...

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Autores principales: Sheng Tang, Barbara Terzic, I-Ting Judy Wang, Nicolas Sarmiento, Katherine Sizov, Yue Cui, Hajime Takano, Eric D. Marsh, Zhaolan Zhou, Douglas A. Coulter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/fcc09e9d517f46139fc63936735506c3
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