Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging

Multiphoton microscopy requires precise increases in excitation power with imaging depth to generate contrast without damaging the sample. Here the authors show how an adaptive illumination function can be learned from the sample’s shape and used for in vivo imaging of whole lymph nodes.

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Autores principales:	Henry Pinkard, Hratch Baghdassarian, Adriana Mujal, Ed Roberts, Kenneth H. Hu, Daniel Haim Friedman, Ivana Malenica, Taylor Shagam, Adam Fries, Kaitlin Corbin, Matthew F. Krummel, Laura Waller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcc73bb7eff54047abea2f8a85694bb0
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spelling	oai:doaj.org-article:fcc73bb7eff54047abea2f8a85694bb02021-12-02T11:44:56ZLearned adaptive multiphoton illumination microscopy for large-scale immune response imaging10.1038/s41467-021-22246-52041-1723https://doaj.org/article/fcc73bb7eff54047abea2f8a85694bb02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22246-5https://doaj.org/toc/2041-1723Multiphoton microscopy requires precise increases in excitation power with imaging depth to generate contrast without damaging the sample. Here the authors show how an adaptive illumination function can be learned from the sample’s shape and used for in vivo imaging of whole lymph nodes.Henry PinkardHratch BaghdassarianAdriana MujalEd RobertsKenneth H. HuDaniel Haim FriedmanIvana MalenicaTaylor ShagamAdam FriesKaitlin CorbinMatthew F. KrummelLaura WallerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Henry Pinkard Hratch Baghdassarian Adriana Mujal Ed Roberts Kenneth H. Hu Daniel Haim Friedman Ivana Malenica Taylor Shagam Adam Fries Kaitlin Corbin Matthew F. Krummel Laura Waller Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
description	Multiphoton microscopy requires precise increases in excitation power with imaging depth to generate contrast without damaging the sample. Here the authors show how an adaptive illumination function can be learned from the sample’s shape and used for in vivo imaging of whole lymph nodes.
format	article
author	Henry Pinkard Hratch Baghdassarian Adriana Mujal Ed Roberts Kenneth H. Hu Daniel Haim Friedman Ivana Malenica Taylor Shagam Adam Fries Kaitlin Corbin Matthew F. Krummel Laura Waller
author_facet	Henry Pinkard Hratch Baghdassarian Adriana Mujal Ed Roberts Kenneth H. Hu Daniel Haim Friedman Ivana Malenica Taylor Shagam Adam Fries Kaitlin Corbin Matthew F. Krummel Laura Waller
author_sort	Henry Pinkard
title	Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
title_short	Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
title_full	Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
title_fullStr	Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
title_full_unstemmed	Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
title_sort	learned adaptive multiphoton illumination microscopy for large-scale immune response imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fcc73bb7eff54047abea2f8a85694bb0
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Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging

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