NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19
Objective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19. Study design: Descriptive comparative study. Place and Duration of study: Department of Medicine, CMH Thal from April to...
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Army Medical College Rawalpindi
2020
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| Acceso en línea: | https://doi.org/10.51253/pafmj.v70i6.5010 https://doaj.org/article/fcc7efe337174fab8d36de392824c7a4 |
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oai:doaj.org-article:fcc7efe337174fab8d36de392824c7a42021-12-02T17:16:23ZNEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19https://doi.org/10.51253/pafmj.v70i6.50100030-96482411-8842https://doaj.org/article/fcc7efe337174fab8d36de392824c7a42020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5010https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19. Study design: Descriptive comparative study. Place and Duration of study: Department of Medicine, CMH Thal from April to July, 2020 Patients & Methods: 61 patients of COVID-19 confirmed through polymerase chain reaction were recruited and divided into severe and non severe disease. Complete blood counts were done. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio were calculated and analyzed. Results: 14 patients (23%) of severe disease had mean age of 49.93±19.42 and 47 patients (77%) with non-severe disease had mean age of 33.32±9.16. The mean Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte ratio in patients who had severe disease was 7.20±4.20 and 204.25±148.42 (p=0.001 and p=0.026) respectively. The diagnostic performance of both Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio produced statistically significant area under the curve (AUC), (p <0.001). The adjusted and unadjusted area under curve for Neutrophil to Lymphocyte Ratio was 0.92 (95% CI: 0.85–1.00) and 0.923 (95% CI: 0.839-1.000) and for Platelet to Lymphocyte Ratio it was 0.883 (95% CI: 0.781–0.985) and 0.825(95% CI: 0.707-0.943) respectively. Conclusion: Elevated Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are independent biomarkers which predict severity of disease in COVID-19 patients with Neutrophil to Lymphocyte Ratio being better predictor in terms of diagnostic accuracy. Muhammad AdilZahid Farooq BaigMuhammad AmirSohail Saqib ChathaAamir HabibMuhammad MajidArmy Medical College Rawalpindiarticlecorona virus disease 2019 (covid‐19)neutrophil to lymphocyte ratioplatelet to lymphocyte ratioMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1609-1615 (2020) |
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corona virus disease 2019 (covid‐19) neutrophil to lymphocyte ratio platelet to lymphocyte ratio Medicine R Medicine (General) R5-920 |
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corona virus disease 2019 (covid‐19) neutrophil to lymphocyte ratio platelet to lymphocyte ratio Medicine R Medicine (General) R5-920 Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| description |
Objective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19.
Study design: Descriptive comparative study.
Place and Duration of study: Department of Medicine, CMH Thal from April to July, 2020
Patients & Methods: 61 patients of COVID-19 confirmed through polymerase chain reaction were recruited and divided into severe and non severe disease. Complete blood counts were done. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio were calculated and analyzed.
Results: 14 patients (23%) of severe disease had mean age of 49.93±19.42 and 47 patients (77%) with non-severe disease had mean age of 33.32±9.16. The mean Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte ratio in patients who had severe disease was 7.20±4.20 and 204.25±148.42 (p=0.001 and p=0.026) respectively. The diagnostic performance of both Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio produced statistically significant area under the curve (AUC), (p <0.001). The adjusted and unadjusted area under curve for Neutrophil to Lymphocyte Ratio was 0.92 (95% CI: 0.85–1.00) and 0.923 (95% CI: 0.839-1.000) and for Platelet to Lymphocyte Ratio it was 0.883 (95% CI: 0.781–0.985) and 0.825(95% CI: 0.707-0.943) respectively.
Conclusion: Elevated Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are independent biomarkers which predict severity of disease in COVID-19 patients with Neutrophil to Lymphocyte Ratio being better predictor in terms of diagnostic accuracy. |
| format |
article |
| author |
Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid |
| author_facet |
Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid |
| author_sort |
Muhammad Adil |
| title |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| title_short |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| title_full |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| title_fullStr |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| title_full_unstemmed |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
| title_sort |
neutrophil to lymphocyte ratio vs platelets to lymphocyte ratio: biomarkers to predict severity of disease and their comparison in patients of covid-19 |
| publisher |
Army Medical College Rawalpindi |
| publishDate |
2020 |
| url |
https://doi.org/10.51253/pafmj.v70i6.5010 https://doaj.org/article/fcc7efe337174fab8d36de392824c7a4 |
| work_keys_str_mv |
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| _version_ |
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