Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-rea...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yu Adachi, Keisuke Tonouchi, Arnone Nithichanon, Masayuki Kuraoka, Akiko Watanabe, Ryo Shinnakasu, Hideki Asanuma, Akira Ainai, Yusuke Ohmi, Takuya Yamamoto, Ken J. Ishii, Hideki Hasegawa, Haruko Takeyama, Ganjana Lertmemongkolchai, Tomohiro Kurosaki, Manabu Ato, Garnett Kelsoe, Yoshimasa Takahashi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fcc9b042359d4d5ca91778a784a13526
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fcc9b042359d4d5ca91778a784a13526
record_format dspace
spelling oai:doaj.org-article:fcc9b042359d4d5ca91778a784a135262021-12-02T14:35:44ZExposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies10.1038/s41467-019-11821-62041-1723https://doaj.org/article/fcc9b042359d4d5ca91778a784a135262019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11821-6https://doaj.org/toc/2041-1723Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.Yu AdachiKeisuke TonouchiArnone NithichanonMasayuki KuraokaAkiko WatanabeRyo ShinnakasuHideki AsanumaAkira AinaiYusuke OhmiTakuya YamamotoKen J. IshiiHideki HasegawaHaruko TakeyamaGanjana LertmemongkolchaiTomohiro KurosakiManabu AtoGarnett KelsoeYoshimasa TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
description Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.
format article
author Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
author_facet Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
author_sort Yu Adachi
title Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_short Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_full Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_fullStr Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_full_unstemmed Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_sort exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/fcc9b042359d4d5ca91778a784a13526
work_keys_str_mv AT yuadachi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT keisuketonouchi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT arnonenithichanon exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT masayukikuraoka exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT akikowatanabe exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT ryoshinnakasu exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT hidekiasanuma exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT akiraainai exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT yusukeohmi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT takuyayamamoto exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT kenjishii exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT hidekihasegawa exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT harukotakeyama exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT ganjanalertmemongkolchai exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT tomohirokurosaki exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT manabuato exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT garnettkelsoe exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT yoshimasatakahashi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
_version_ 1718391110522372096

Ejemplares similares