Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles
Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-spec...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:fccca1218e5642209b82290022034c3b2021-12-01T17:59:50ZEfficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles2296-418510.3389/fbioe.2021.762956https://doaj.org/article/fccca1218e5642209b82290022034c3b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.762956/fullhttps://doaj.org/toc/2296-4185Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.Chuangjia HuangChuangjia HuangXiaoling GuanXiaoling GuanHui LinLu LiangLu LiangYingling MiaoYingling MiaoYueheng WuHuiqiong BaoXiaodan WuXiaodan WuAo ShenAo ShenMinyan WeiMinyan WeiJionghua HuangFrontiers Media S.A.articleICGmesoporous silica nanoparticlescell membrane coatingphotoacoustic imagingcervical carcinomaBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
ICG mesoporous silica nanoparticles cell membrane coating photoacoustic imaging cervical carcinoma Biotechnology TP248.13-248.65 |
| spellingShingle |
ICG mesoporous silica nanoparticles cell membrane coating photoacoustic imaging cervical carcinoma Biotechnology TP248.13-248.65 Chuangjia Huang Chuangjia Huang Xiaoling Guan Xiaoling Guan Hui Lin Lu Liang Lu Liang Yingling Miao Yingling Miao Yueheng Wu Huiqiong Bao Xiaodan Wu Xiaodan Wu Ao Shen Ao Shen Minyan Wei Minyan Wei Jionghua Huang Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| description |
Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma. |
| format |
article |
| author |
Chuangjia Huang Chuangjia Huang Xiaoling Guan Xiaoling Guan Hui Lin Lu Liang Lu Liang Yingling Miao Yingling Miao Yueheng Wu Huiqiong Bao Xiaodan Wu Xiaodan Wu Ao Shen Ao Shen Minyan Wei Minyan Wei Jionghua Huang |
| author_facet |
Chuangjia Huang Chuangjia Huang Xiaoling Guan Xiaoling Guan Hui Lin Lu Liang Lu Liang Yingling Miao Yingling Miao Yueheng Wu Huiqiong Bao Xiaodan Wu Xiaodan Wu Ao Shen Ao Shen Minyan Wei Minyan Wei Jionghua Huang |
| author_sort |
Chuangjia Huang |
| title |
Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| title_short |
Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| title_full |
Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| title_fullStr |
Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| title_full_unstemmed |
Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles |
| title_sort |
efficient photoacoustic imaging with biomimetic mesoporous silica-based nanoparticles |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/fccca1218e5642209b82290022034c3b |
| work_keys_str_mv |
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1718404790959996928 |