Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia

Abstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuan-Yuei Chen, Tung-Wei Kao, Cheng-Wai Chou, Chen-Jung Wu, Hui-Fang Yang, Ching-Huang Lai, Li-Wei Wu, Wei-Liang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fccec3de7ea542578a719aa26f9ce70d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fccec3de7ea542578a719aa26f9ce70d
record_format	dspace
spelling	oai:doaj.org-article:fccec3de7ea542578a719aa26f9ce70d2021-12-02T12:32:47ZExploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia10.1038/s41598-018-21784-12045-2322https://doaj.org/article/fccec3de7ea542578a719aa26f9ce70d2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21784-1https://doaj.org/toc/2045-2322Abstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses. Within the normal range of serum phosphate, we used quartile-based analyses to determine the potential relationships of serum phosphate with dynapenia, and sarcopenia through multivariate regression models. After adjusting for the pertinent variables, an inverse association between the serum phosphate quartiles and muscle strength was observed and the linear association was stronger than other anthropometric parameters. Notably, the significant association between phosphate and muscle strength was existed in >65 years old age group, not in 20–65 years old. The higher quartiles of phosphate had higher likelihood for predicting the presence of dynapenia rather than sarcopenia in entire population. Our study highlighted that higher quartiles of phosphate had significant association with lower muscle strength and higher risks for predicting the presence of dynapenia.Yuan-Yuei ChenTung-Wei KaoCheng-Wai ChouChen-Jung WuHui-Fang YangChing-Huang LaiLi-Wei WuWei-Liang ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
description	Abstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses. Within the normal range of serum phosphate, we used quartile-based analyses to determine the potential relationships of serum phosphate with dynapenia, and sarcopenia through multivariate regression models. After adjusting for the pertinent variables, an inverse association between the serum phosphate quartiles and muscle strength was observed and the linear association was stronger than other anthropometric parameters. Notably, the significant association between phosphate and muscle strength was existed in >65 years old age group, not in 20–65 years old. The higher quartiles of phosphate had higher likelihood for predicting the presence of dynapenia rather than sarcopenia in entire population. Our study highlighted that higher quartiles of phosphate had significant association with lower muscle strength and higher risks for predicting the presence of dynapenia.
format	article
author	Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen
author_facet	Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen
author_sort	Yuan-Yuei Chen
title	Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
title_short	Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
title_full	Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
title_fullStr	Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
title_full_unstemmed	Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
title_sort	exploring the link between serum phosphate levels and low muscle strength, dynapenia, and sarcopenia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fccec3de7ea542578a719aa26f9ce70d
work_keys_str_mv	AT yuanyueichen exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT tungweikao exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT chengwaichou exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT chenjungwu exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT huifangyang exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT chinghuanglai exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT liweiwu exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia AT weiliangchen exploringthelinkbetweenserumphosphatelevelsandlowmusclestrengthdynapeniaandsarcopenia
_version_	1718394016208257024

Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia

Ejemplares similares