Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus

Glyphosate is a pesticide that influences many blood parameters if taken orally or subcutaneously. This pesticide causes important changes in the metabolic activity which can be measured by organospecific enzyme activity such as liver aminotransferases (AST and ALT), while glucose acts as a stress,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hasković Edhem, Pekić Melina, Fočak Muhamed, Suljević Damir, Mešalić Lejla
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	alt ast serum glucose glyphosate ldh wistar strain rat Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fcd0b40f6de741f78a70c1bc3068b28b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fcd0b40f6de741f78a70c1bc3068b28b
record_format	dspace
spelling	oai:doaj.org-article:fcd0b40f6de741f78a70c1bc3068b28b2021-11-17T21:27:51ZEffects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus1820-744810.1515/acve-2016-0018https://doaj.org/article/fcd0b40f6de741f78a70c1bc3068b28b2016-06-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0018https://doaj.org/toc/1820-7448Glyphosate is a pesticide that influences many blood parameters if taken orally or subcutaneously. This pesticide causes important changes in the metabolic activity which can be measured by organospecific enzyme activity such as liver aminotransferases (AST and ALT), while glucose acts as a stress, energy and metabolism indicator after acute glyphosate exposure. In this research, glyphosate was applied subcutaneously to rats, administrated each 24 hours for a 15 days period. The concentration of the applied glyphosate was 2.8 g/kg. The experimental rats were 13 weeks old. The concentration of serum glucose, the activity of lactate dehydrogenase and liver transaminases (AST and ALT) were observed as indicators of metabolic changes after treatment. It was observed that glyphosate led to a statistically significant decrease of serum glucose level. Statistically significantly increased (p<0.05) AST, ALT and LDH activities are indicators of hepatocyte damage while LDH activity demonstrates damage of other tissues.Hasković EdhemPekić MelinaFočak MuhamedSuljević DamirMešalić LejlaSciendoarticlealtastserum glucoseglyphosateldhwistar strain ratVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 2, Pp 214-221 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	alt ast serum glucose glyphosate ldh wistar strain rat Veterinary medicine SF600-1100
spellingShingle	alt ast serum glucose glyphosate ldh wistar strain rat Veterinary medicine SF600-1100 Hasković Edhem Pekić Melina Fočak Muhamed Suljević Damir Mešalić Lejla Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
description	Glyphosate is a pesticide that influences many blood parameters if taken orally or subcutaneously. This pesticide causes important changes in the metabolic activity which can be measured by organospecific enzyme activity such as liver aminotransferases (AST and ALT), while glucose acts as a stress, energy and metabolism indicator after acute glyphosate exposure. In this research, glyphosate was applied subcutaneously to rats, administrated each 24 hours for a 15 days period. The concentration of the applied glyphosate was 2.8 g/kg. The experimental rats were 13 weeks old. The concentration of serum glucose, the activity of lactate dehydrogenase and liver transaminases (AST and ALT) were observed as indicators of metabolic changes after treatment. It was observed that glyphosate led to a statistically significant decrease of serum glucose level. Statistically significantly increased (p<0.05) AST, ALT and LDH activities are indicators of hepatocyte damage while LDH activity demonstrates damage of other tissues.
format	article
author	Hasković Edhem Pekić Melina Fočak Muhamed Suljević Damir Mešalić Lejla
author_facet	Hasković Edhem Pekić Melina Fočak Muhamed Suljević Damir Mešalić Lejla
author_sort	Hasković Edhem
title	Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
title_short	Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
title_full	Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
title_fullStr	Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
title_full_unstemmed	Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
title_sort	effects of glyphosate on enzyme activity and serum glucose in rats rattus norvegicus
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/fcd0b40f6de741f78a70c1bc3068b28b
work_keys_str_mv	AT haskovicedhem effectsofglyphosateonenzymeactivityandserumglucoseinratsrattusnorvegicus AT pekicmelina effectsofglyphosateonenzymeactivityandserumglucoseinratsrattusnorvegicus AT focakmuhamed effectsofglyphosateonenzymeactivityandserumglucoseinratsrattusnorvegicus AT suljevicdamir effectsofglyphosateonenzymeactivityandserumglucoseinratsrattusnorvegicus AT mesaliclejla effectsofglyphosateonenzymeactivityandserumglucoseinratsrattusnorvegicus
_version_	1718425329408671744

Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus

Ejemplares similares