Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplic...

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Autores principales: Elena Lazzeri, Maria Lucia Angelotti, Anna Peired, Carolina Conte, Julian A. Marschner, Laura Maggi, Benedetta Mazzinghi, Duccio Lombardi, Maria Elena Melica, Sara Nardi, Elisa Ronconi, Alessandro Sisti, Giulia Antonelli, Francesca Becherucci, Letizia De Chiara, Ricardo Romero Guevara, Alexa Burger, Beat Schaefer, Francesco Annunziato, Hans-Joachim Anders, Laura Lasagni, Paola Romagnani
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fcd2644ead064a62bdd2370d3ecae9a3
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spelling oai:doaj.org-article:fcd2644ead064a62bdd2370d3ecae9a32021-12-02T17:33:18ZEndocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury10.1038/s41467-018-03753-42041-1723https://doaj.org/article/fcd2644ead064a62bdd2370d3ecae9a32018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03753-4https://doaj.org/toc/2041-1723The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.Elena LazzeriMaria Lucia AngelottiAnna PeiredCarolina ConteJulian A. MarschnerLaura MaggiBenedetta MazzinghiDuccio LombardiMaria Elena MelicaSara NardiElisa RonconiAlessandro SistiGiulia AntonelliFrancesca BecherucciLetizia De ChiaraRicardo Romero GuevaraAlexa BurgerBeat SchaeferFrancesco AnnunziatoHans-Joachim AndersLaura LasagniPaola RomagnaniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elena Lazzeri
Maria Lucia Angelotti
Anna Peired
Carolina Conte
Julian A. Marschner
Laura Maggi
Benedetta Mazzinghi
Duccio Lombardi
Maria Elena Melica
Sara Nardi
Elisa Ronconi
Alessandro Sisti
Giulia Antonelli
Francesca Becherucci
Letizia De Chiara
Ricardo Romero Guevara
Alexa Burger
Beat Schaefer
Francesco Annunziato
Hans-Joachim Anders
Laura Lasagni
Paola Romagnani
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
description The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.
format article
author Elena Lazzeri
Maria Lucia Angelotti
Anna Peired
Carolina Conte
Julian A. Marschner
Laura Maggi
Benedetta Mazzinghi
Duccio Lombardi
Maria Elena Melica
Sara Nardi
Elisa Ronconi
Alessandro Sisti
Giulia Antonelli
Francesca Becherucci
Letizia De Chiara
Ricardo Romero Guevara
Alexa Burger
Beat Schaefer
Francesco Annunziato
Hans-Joachim Anders
Laura Lasagni
Paola Romagnani
author_facet Elena Lazzeri
Maria Lucia Angelotti
Anna Peired
Carolina Conte
Julian A. Marschner
Laura Maggi
Benedetta Mazzinghi
Duccio Lombardi
Maria Elena Melica
Sara Nardi
Elisa Ronconi
Alessandro Sisti
Giulia Antonelli
Francesca Becherucci
Letizia De Chiara
Ricardo Romero Guevara
Alexa Burger
Beat Schaefer
Francesco Annunziato
Hans-Joachim Anders
Laura Lasagni
Paola Romagnani
author_sort Elena Lazzeri
title Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
title_short Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
title_full Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
title_fullStr Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
title_full_unstemmed Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
title_sort endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fcd2644ead064a62bdd2370d3ecae9a3
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