On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy

Fatemeh S Rasouli,1 S Farhad Masoudi,1 Somayeh Asadi21Department of Physics, K.N. Toosi University of Technology, Tehran, Iran; 2Department of Mechanical Engineering, Politecnico Di Milano, Milan, ItalyPurpose: To investigate the effect of precise modeling for Monte Carlo simulations of gold nanopar...

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Autores principales:	Rasouli FS, Masoudi SF, Asadi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	‎Gold nanoparticles‎ ‎Dose-enhanced radiotherapy‎ ‎Cell model‎ ‎Tumor‎ ‎Monte Carlo simulation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fcd9fff8e4f3411db1f1e65cf5a19f35
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spelling	oai:doaj.org-article:fcd9fff8e4f3411db1f1e65cf5a19f352021-12-02T07:04:36ZOn the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy1178-2013https://doaj.org/article/fcd9fff8e4f3411db1f1e65cf5a19f352019-07-01T00:00:00Zhttps://www.dovepress.com/on-the-importance-of-modeling-gold-nanoparticles-distribution-in-dose--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fatemeh S Rasouli,1 S Farhad Masoudi,1 Somayeh Asadi21Department of Physics, K.N. Toosi University of Technology, Tehran, Iran; 2Department of Mechanical Engineering, Politecnico Di Milano, Milan, ItalyPurpose: To investigate the effect of precise modeling for Monte Carlo simulations of gold nanoparticles (GNPs) dose-enhanced radiotherapy, two models characterized by their distribution of GNPs in a simulated macroscopic cubic tumor were introduced. The motivation was the widely documented tendency of GNPs to localize around the cell nucleus.Methods: The introduced models composed of 2.7×107 ellipsoid cells, each of them containing a centrally located nucleus as the target for dose evaluation. In the first model, the spheres of GNP are homogeneously distributed in the whole tumor volume, and in the latter, GNPs are localized in the cytoplasms surrounded the nuclei.Results: The results achieved through applying Monte Carlo radiation transports using the Mont Carlo N-Particle eXtended code (MCNPX) show an underestimation of nuclear dose enhancement caused by homogeneous model compared with that of heterogeneous distribution. By investigating various quantities, it was found that subcellular location of GNPs strongly governs the sensitivity of dose enhancement to the number and concentration of GNPs targeted in the tumor. Other obvious differences are revealed by studying the dose enhancement curves in depth of the tumor. While the heterogeneous model predicts an approximately constant dose enhancement in depth for primary photon energies of 50 keV and more, the homogeneous model estimates an energy-dependent increase of about 11 to 30%.Conclusion: It can be concluded that defining a model in accordance with the experimental observations can effectively account for accurate prediction of macroscopic dose enhancement in the target of interest.Keywords: gold nanoparticles, dose-enhanced radiotherapy, cell model, tumor, Monte Carlo simulationRasouli FSMasoudi SFAsadi SDove Medical Pressarticle‎Gold nanoparticles‎‎Dose-enhanced radiotherapy‎‎Cell model‎‎Tumor‎‎Monte Carlo simulationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5865-5874 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	‎Gold nanoparticles‎ ‎Dose-enhanced radiotherapy‎ ‎Cell model‎ ‎Tumor‎ ‎Monte Carlo simulation Medicine (General) R5-920
spellingShingle	‎Gold nanoparticles‎ ‎Dose-enhanced radiotherapy‎ ‎Cell model‎ ‎Tumor‎ ‎Monte Carlo simulation Medicine (General) R5-920 Rasouli FS Masoudi SF Asadi S On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
description	Fatemeh S Rasouli,1 S Farhad Masoudi,1 Somayeh Asadi21Department of Physics, K.N. Toosi University of Technology, Tehran, Iran; 2Department of Mechanical Engineering, Politecnico Di Milano, Milan, ItalyPurpose: To investigate the effect of precise modeling for Monte Carlo simulations of gold nanoparticles (GNPs) dose-enhanced radiotherapy, two models characterized by their distribution of GNPs in a simulated macroscopic cubic tumor were introduced. The motivation was the widely documented tendency of GNPs to localize around the cell nucleus.Methods: The introduced models composed of 2.7×107 ellipsoid cells, each of them containing a centrally located nucleus as the target for dose evaluation. In the first model, the spheres of GNP are homogeneously distributed in the whole tumor volume, and in the latter, GNPs are localized in the cytoplasms surrounded the nuclei.Results: The results achieved through applying Monte Carlo radiation transports using the Mont Carlo N-Particle eXtended code (MCNPX) show an underestimation of nuclear dose enhancement caused by homogeneous model compared with that of heterogeneous distribution. By investigating various quantities, it was found that subcellular location of GNPs strongly governs the sensitivity of dose enhancement to the number and concentration of GNPs targeted in the tumor. Other obvious differences are revealed by studying the dose enhancement curves in depth of the tumor. While the heterogeneous model predicts an approximately constant dose enhancement in depth for primary photon energies of 50 keV and more, the homogeneous model estimates an energy-dependent increase of about 11 to 30%.Conclusion: It can be concluded that defining a model in accordance with the experimental observations can effectively account for accurate prediction of macroscopic dose enhancement in the target of interest.Keywords: gold nanoparticles, dose-enhanced radiotherapy, cell model, tumor, Monte Carlo simulation
format	article
author	Rasouli FS Masoudi SF Asadi S
author_facet	Rasouli FS Masoudi SF Asadi S
author_sort	Rasouli FS
title	On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
title_short	On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
title_full	On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
title_fullStr	On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
title_full_unstemmed	On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
title_sort	on the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fcd9fff8e4f3411db1f1e65cf5a19f35
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On the importance of modeling gold nanoparticles distribution in dose-enhanced radiotherapy

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