Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory

Abstract Social behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer’s disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social...

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Autores principales:	Kana Okada, Kayo Nishizawa, Tomoko Kobayashi, Shogo Sakata, Kouichi Hashimoto, Kazuto Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fcda3ed186494775b86cf27b2b830981
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spelling	oai:doaj.org-article:fcda3ed186494775b86cf27b2b8309812021-12-02T18:18:51ZDifferent cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory10.1038/s41598-021-93045-72045-2322https://doaj.org/article/fcda3ed186494775b86cf27b2b8309812021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93045-7https://doaj.org/toc/2045-2322Abstract Social behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer’s disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber test. Elimination of cholinergic neurons in the medial septum (MS) and vertical diagonal band of Broca (vDB) caused impairment in social interaction, whereas ablating cholinergic neurons in the nucleus basalis magnocellularis (NBM) impaired social recognition memory. These impairments were restored by treatment with cholinesterase inhibitors, leading to cholinergic system activation. Our findings indicate distinct roles of MS/vDB and NBM cholinergic neurons in social interaction and social recognition memory, suggesting that cholinergic dysfunction may explain social ability deficits associated with AD symptoms.Kana OkadaKayo NishizawaTomoko KobayashiShogo SakataKouichi HashimotoKazuto KobayashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kana Okada Kayo Nishizawa Tomoko Kobayashi Shogo Sakata Kouichi Hashimoto Kazuto Kobayashi Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
description	Abstract Social behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer’s disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber test. Elimination of cholinergic neurons in the medial septum (MS) and vertical diagonal band of Broca (vDB) caused impairment in social interaction, whereas ablating cholinergic neurons in the nucleus basalis magnocellularis (NBM) impaired social recognition memory. These impairments were restored by treatment with cholinesterase inhibitors, leading to cholinergic system activation. Our findings indicate distinct roles of MS/vDB and NBM cholinergic neurons in social interaction and social recognition memory, suggesting that cholinergic dysfunction may explain social ability deficits associated with AD symptoms.
format	article
author	Kana Okada Kayo Nishizawa Tomoko Kobayashi Shogo Sakata Kouichi Hashimoto Kazuto Kobayashi
author_facet	Kana Okada Kayo Nishizawa Tomoko Kobayashi Shogo Sakata Kouichi Hashimoto Kazuto Kobayashi
author_sort	Kana Okada
title	Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
title_short	Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
title_full	Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
title_fullStr	Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
title_full_unstemmed	Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
title_sort	different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fcda3ed186494775b86cf27b2b830981
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_version_	1718378193160765440

Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory

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