Yokukansan and its ingredients as possible treatment options for schizophrenia

Chuan-Hsun Yu,1 Ryouhei Ishii,2 Shun-Chieh Yu,1 Masatoshi Takeda2 1Yuli Hospital, Department of Health, Hualien, Taiwan; 2Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan Abstract: Schizophrenia is a debilitating psychotic mental disorder that affects almost th...

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Autores principales: Yu CH, Ishii R, Yu SC, Takeda M
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Lenguaje:EN
Publicado: Dove Medical Press 2014
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spelling oai:doaj.org-article:fcda9a1a0f674ee1bcb444de8773ba052021-12-02T00:25:59ZYokukansan and its ingredients as possible treatment options for schizophrenia1178-2021https://doaj.org/article/fcda9a1a0f674ee1bcb444de8773ba052014-09-01T00:00:00Zhttp://www.dovepress.com/yokukansan-and-its-ingredients-as-possible-treatment-options-for-schiz-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Chuan-Hsun Yu,1 Ryouhei Ishii,2 Shun-Chieh Yu,1 Masatoshi Takeda2 1Yuli Hospital, Department of Health, Hualien, Taiwan; 2Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan Abstract: Schizophrenia is a debilitating psychotic mental disorder that affects almost the entire range of human mental function. The devastating effect of the illness is usually long-lasting and requires lifelong treatment. Despite an evolved psychopharmacological understanding, the overall therapeutic effect of antipsychotics is still not satisfactory. The choice of proper medication presents a clinical dilemma between efficacy and safety. As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi-gan san in Chinese, is a traditional herbal medicine with evident therapeutic effect for neuropsychiatric disorders. There are several open-label clinical studies upholding the possibility of using yokukansan to treat schizophrenia or schizophrenia-like psychosis. Evidence from animal studies and neurobiology also sheds light on the antipsychotic implications of yokukansan and its ingredients. Nevertheless, correlations between the experimental environment and clinical settings may be complicated by a number of confounders. Clinical trials with more sophisticated designs are required to fill the gap between the experimental environment and clinical settings. Keywords: herbal medicine, geissoschizine methyl ether, glycyrrhizin, antipsychotics, D2 receptorYu CHIshii RYu SCTakeda MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1629-1634 (2014)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Yu CH
Ishii R
Yu SC
Takeda M
Yokukansan and its ingredients as possible treatment options for schizophrenia
description Chuan-Hsun Yu,1 Ryouhei Ishii,2 Shun-Chieh Yu,1 Masatoshi Takeda2 1Yuli Hospital, Department of Health, Hualien, Taiwan; 2Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan Abstract: Schizophrenia is a debilitating psychotic mental disorder that affects almost the entire range of human mental function. The devastating effect of the illness is usually long-lasting and requires lifelong treatment. Despite an evolved psychopharmacological understanding, the overall therapeutic effect of antipsychotics is still not satisfactory. The choice of proper medication presents a clinical dilemma between efficacy and safety. As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi-gan san in Chinese, is a traditional herbal medicine with evident therapeutic effect for neuropsychiatric disorders. There are several open-label clinical studies upholding the possibility of using yokukansan to treat schizophrenia or schizophrenia-like psychosis. Evidence from animal studies and neurobiology also sheds light on the antipsychotic implications of yokukansan and its ingredients. Nevertheless, correlations between the experimental environment and clinical settings may be complicated by a number of confounders. Clinical trials with more sophisticated designs are required to fill the gap between the experimental environment and clinical settings. Keywords: herbal medicine, geissoschizine methyl ether, glycyrrhizin, antipsychotics, D2 receptor
format article
author Yu CH
Ishii R
Yu SC
Takeda M
author_facet Yu CH
Ishii R
Yu SC
Takeda M
author_sort Yu CH
title Yokukansan and its ingredients as possible treatment options for schizophrenia
title_short Yokukansan and its ingredients as possible treatment options for schizophrenia
title_full Yokukansan and its ingredients as possible treatment options for schizophrenia
title_fullStr Yokukansan and its ingredients as possible treatment options for schizophrenia
title_full_unstemmed Yokukansan and its ingredients as possible treatment options for schizophrenia
title_sort yokukansan and its ingredients as possible treatment options for schizophrenia
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/fcda9a1a0f674ee1bcb444de8773ba05
work_keys_str_mv AT yuch yokukansananditsingredientsaspossibletreatmentoptionsforschizophrenia
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AT yusc yokukansananditsingredientsaspossibletreatmentoptionsforschizophrenia
AT takedam yokukansananditsingredientsaspossibletreatmentoptionsforschizophrenia
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