Role of reactive oxygen species in male infertility: An updated review of literature

Objectives: To review the literature and provide an updated summary on the role of reactive oxygen species (ROS) in male infertility. Methods: A review of PubMed, Cochrane review, and Web of Science databases for full-text English-language articles published between 1943 and 2017 was performed, focu...

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Autores principales:	Hillary Wagner, Julie W. Cheng, Edmund Y. Ko
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/fce15f515f774ff8939b97b9b60b3775
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spelling	oai:doaj.org-article:fce15f515f774ff8939b97b9b60b37752021-12-02T10:36:47ZRole of reactive oxygen species in male infertility: An updated review of literature2090-598X10.1016/j.aju.2017.11.001https://doaj.org/article/fce15f515f774ff8939b97b9b60b37752018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301316https://doaj.org/toc/2090-598XObjectives: To review the literature and provide an updated summary on the role of reactive oxygen species (ROS) in male infertility. Methods: A review of PubMed, Cochrane review, and Web of Science databases for full-text English-language articles published between 1943 and 2017 was performed, focusing on the aetiology of ROS, physiological role of ROS on spermatic function, pathological role of ROS in infertility, evaluation of ROS, and role of antioxidants in oxidative stress. Results: ROS play a role in spermatic function and fertilisation. The literature describes both a physiological and a pathological role of ROS in fertility. A delicate balance between ROS necessary for physiological activity and antioxidants to protect from cellular oxidative injury is essential for fertility. Conclusion: Although elevated levels of ROS are implicated as a cause of infertility, there is no consensus on selecting patients to test for ROS, which test to perform, or if treatment for ROS can have a positive impact on infertility rates and pregnancy. Keywords: Reactive oxygen species, Male infertility, Free radicals, AntioxidantsHillary WagnerJulie W. ChengEdmund Y. KoTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 35-43 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Hillary Wagner Julie W. Cheng Edmund Y. Ko Role of reactive oxygen species in male infertility: An updated review of literature
description	Objectives: To review the literature and provide an updated summary on the role of reactive oxygen species (ROS) in male infertility. Methods: A review of PubMed, Cochrane review, and Web of Science databases for full-text English-language articles published between 1943 and 2017 was performed, focusing on the aetiology of ROS, physiological role of ROS on spermatic function, pathological role of ROS in infertility, evaluation of ROS, and role of antioxidants in oxidative stress. Results: ROS play a role in spermatic function and fertilisation. The literature describes both a physiological and a pathological role of ROS in fertility. A delicate balance between ROS necessary for physiological activity and antioxidants to protect from cellular oxidative injury is essential for fertility. Conclusion: Although elevated levels of ROS are implicated as a cause of infertility, there is no consensus on selecting patients to test for ROS, which test to perform, or if treatment for ROS can have a positive impact on infertility rates and pregnancy. Keywords: Reactive oxygen species, Male infertility, Free radicals, Antioxidants
format	article
author	Hillary Wagner Julie W. Cheng Edmund Y. Ko
author_facet	Hillary Wagner Julie W. Cheng Edmund Y. Ko
author_sort	Hillary Wagner
title	Role of reactive oxygen species in male infertility: An updated review of literature
title_short	Role of reactive oxygen species in male infertility: An updated review of literature
title_full	Role of reactive oxygen species in male infertility: An updated review of literature
title_fullStr	Role of reactive oxygen species in male infertility: An updated review of literature
title_full_unstemmed	Role of reactive oxygen species in male infertility: An updated review of literature
title_sort	role of reactive oxygen species in male infertility: an updated review of literature
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/fce15f515f774ff8939b97b9b60b3775
work_keys_str_mv	AT hillarywagner roleofreactiveoxygenspeciesinmaleinfertilityanupdatedreviewofliterature AT juliewcheng roleofreactiveoxygenspeciesinmaleinfertilityanupdatedreviewofliterature AT edmundyko roleofreactiveoxygenspeciesinmaleinfertilityanupdatedreviewofliterature
_version_	1718396981901000704

Role of reactive oxygen species in male infertility: An updated review of literature

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