Insights into the Regulation of Ciliary Disassembly

The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical signals to carry out various cellular processes su...

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Autores principales:	Maulin M. Patel, Leonidas Tsiokas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cilia cilia disassembly ciliopathies Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fce71ed181334a9d90579151c5b40ec4
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spelling	oai:doaj.org-article:fce71ed181334a9d90579151c5b40ec42021-11-25T17:09:58ZInsights into the Regulation of Ciliary Disassembly10.3390/cells101129772073-4409https://doaj.org/article/fce71ed181334a9d90579151c5b40ec42021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2977https://doaj.org/toc/2073-4409The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical signals to carry out various cellular processes such as proliferation, migration, differentiation, and many others. At any given time, cilia length is determined by a dynamic balance of cilia assembly and disassembly processes. Abnormally short or long cilia can cause a plethora of human diseases commonly referred to as ciliopathies, including, but not limited to, skeletal malformations, obesity, autosomal dominant polycystic kidney disease, retinal degeneration, and bardet-biedl syndrome. While the process of cilia assembly is studied extensively, the process of cilia disassembly and its biological role(s) are less well understood. This review discusses current knowledge on ciliary disassembly and how different cellular processes and molecular signals converge to carry out this process. This information will help us understand how the process of ciliary disassembly is regulated, identify the key steps that need further investigation, and possibly design therapeutic targets for a subset of ciliopathies that are causally linked to defective ciliary disassembly.Maulin M. PatelLeonidas TsiokasMDPI AGarticleciliacilia disassemblyciliopathiesBiology (General)QH301-705.5ENCells, Vol 10, Iss 2977, p 2977 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cilia cilia disassembly ciliopathies Biology (General) QH301-705.5
spellingShingle	cilia cilia disassembly ciliopathies Biology (General) QH301-705.5 Maulin M. Patel Leonidas Tsiokas Insights into the Regulation of Ciliary Disassembly
description	The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical signals to carry out various cellular processes such as proliferation, migration, differentiation, and many others. At any given time, cilia length is determined by a dynamic balance of cilia assembly and disassembly processes. Abnormally short or long cilia can cause a plethora of human diseases commonly referred to as ciliopathies, including, but not limited to, skeletal malformations, obesity, autosomal dominant polycystic kidney disease, retinal degeneration, and bardet-biedl syndrome. While the process of cilia assembly is studied extensively, the process of cilia disassembly and its biological role(s) are less well understood. This review discusses current knowledge on ciliary disassembly and how different cellular processes and molecular signals converge to carry out this process. This information will help us understand how the process of ciliary disassembly is regulated, identify the key steps that need further investigation, and possibly design therapeutic targets for a subset of ciliopathies that are causally linked to defective ciliary disassembly.
format	article
author	Maulin M. Patel Leonidas Tsiokas
author_facet	Maulin M. Patel Leonidas Tsiokas
author_sort	Maulin M. Patel
title	Insights into the Regulation of Ciliary Disassembly
title_short	Insights into the Regulation of Ciliary Disassembly
title_full	Insights into the Regulation of Ciliary Disassembly
title_fullStr	Insights into the Regulation of Ciliary Disassembly
title_full_unstemmed	Insights into the Regulation of Ciliary Disassembly
title_sort	insights into the regulation of ciliary disassembly
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fce71ed181334a9d90579151c5b40ec4
work_keys_str_mv	AT maulinmpatel insightsintotheregulationofciliarydisassembly AT leonidastsiokas insightsintotheregulationofciliarydisassembly
_version_	1718412690432458752

Insights into the Regulation of Ciliary Disassembly

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