Detection and characterization of lung cancer using cell-free DNA fragmentomes

DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

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Autores principales:	Dimitrios Mathios, Jakob Sidenius Johansen, Stephen Cristiano, Jamie E. Medina, Jillian Phallen, Klaus R. Larsen, Daniel C. Bruhm, Noushin Niknafs, Leonardo Ferreira, Vilmos Adleff, Jia Yuee Chiao, Alessandro Leal, Michael Noe, James R. White, Adith S. Arun, Carolyn Hruban, Akshaya V. Annapragada, Sarah Østrup Jensen, Mai-Britt Worm Ørntoft, Anders Husted Madsen, Beatriz Carvalho, Meike de Wit, Jacob Carey, Nicholas C. Dracopoli, Tara Maddala, Kenneth C. Fang, Anne-Renee Hartman, Patrick M. Forde, Valsamo Anagnostou, Julie R. Brahmer, Remond J. A. Fijneman, Hans Jørgen Nielsen, Gerrit A. Meijer, Claus Lindbjerg Andersen, Anders Mellemgaard, Stig E. Bojesen, Robert B. Scharpf, Victor E. Velculescu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fce9b8c82ce14c3ea1c846a1133812f2
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spelling	oai:doaj.org-article:fce9b8c82ce14c3ea1c846a1133812f22021-12-02T15:10:47ZDetection and characterization of lung cancer using cell-free DNA fragmentomes10.1038/s41467-021-24994-w2041-1723https://doaj.org/article/fce9b8c82ce14c3ea1c846a1133812f22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24994-whttps://doaj.org/toc/2041-1723DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.Dimitrios MathiosJakob Sidenius JohansenStephen CristianoJamie E. MedinaJillian PhallenKlaus R. LarsenDaniel C. BruhmNoushin NiknafsLeonardo FerreiraVilmos AdleffJia Yuee ChiaoAlessandro LealMichael NoeJames R. WhiteAdith S. ArunCarolyn HrubanAkshaya V. AnnapragadaSarah Østrup JensenMai-Britt Worm ØrntoftAnders Husted MadsenBeatriz CarvalhoMeike de WitJacob CareyNicholas C. DracopoliTara MaddalaKenneth C. FangAnne-Renee HartmanPatrick M. FordeValsamo AnagnostouJulie R. BrahmerRemond J. A. FijnemanHans Jørgen NielsenGerrit A. MeijerClaus Lindbjerg AndersenAnders MellemgaardStig E. BojesenRobert B. ScharpfVictor E. VelculescuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dimitrios Mathios Jakob Sidenius Johansen Stephen Cristiano Jamie E. Medina Jillian Phallen Klaus R. Larsen Daniel C. Bruhm Noushin Niknafs Leonardo Ferreira Vilmos Adleff Jia Yuee Chiao Alessandro Leal Michael Noe James R. White Adith S. Arun Carolyn Hruban Akshaya V. Annapragada Sarah Østrup Jensen Mai-Britt Worm Ørntoft Anders Husted Madsen Beatriz Carvalho Meike de Wit Jacob Carey Nicholas C. Dracopoli Tara Maddala Kenneth C. Fang Anne-Renee Hartman Patrick M. Forde Valsamo Anagnostou Julie R. Brahmer Remond J. A. Fijneman Hans Jørgen Nielsen Gerrit A. Meijer Claus Lindbjerg Andersen Anders Mellemgaard Stig E. Bojesen Robert B. Scharpf Victor E. Velculescu Detection and characterization of lung cancer using cell-free DNA fragmentomes
description	DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.
format	article
author	Dimitrios Mathios Jakob Sidenius Johansen Stephen Cristiano Jamie E. Medina Jillian Phallen Klaus R. Larsen Daniel C. Bruhm Noushin Niknafs Leonardo Ferreira Vilmos Adleff Jia Yuee Chiao Alessandro Leal Michael Noe James R. White Adith S. Arun Carolyn Hruban Akshaya V. Annapragada Sarah Østrup Jensen Mai-Britt Worm Ørntoft Anders Husted Madsen Beatriz Carvalho Meike de Wit Jacob Carey Nicholas C. Dracopoli Tara Maddala Kenneth C. Fang Anne-Renee Hartman Patrick M. Forde Valsamo Anagnostou Julie R. Brahmer Remond J. A. Fijneman Hans Jørgen Nielsen Gerrit A. Meijer Claus Lindbjerg Andersen Anders Mellemgaard Stig E. Bojesen Robert B. Scharpf Victor E. Velculescu
author_facet	Dimitrios Mathios Jakob Sidenius Johansen Stephen Cristiano Jamie E. Medina Jillian Phallen Klaus R. Larsen Daniel C. Bruhm Noushin Niknafs Leonardo Ferreira Vilmos Adleff Jia Yuee Chiao Alessandro Leal Michael Noe James R. White Adith S. Arun Carolyn Hruban Akshaya V. Annapragada Sarah Østrup Jensen Mai-Britt Worm Ørntoft Anders Husted Madsen Beatriz Carvalho Meike de Wit Jacob Carey Nicholas C. Dracopoli Tara Maddala Kenneth C. Fang Anne-Renee Hartman Patrick M. Forde Valsamo Anagnostou Julie R. Brahmer Remond J. A. Fijneman Hans Jørgen Nielsen Gerrit A. Meijer Claus Lindbjerg Andersen Anders Mellemgaard Stig E. Bojesen Robert B. Scharpf Victor E. Velculescu
author_sort	Dimitrios Mathios
title	Detection and characterization of lung cancer using cell-free DNA fragmentomes
title_short	Detection and characterization of lung cancer using cell-free DNA fragmentomes
title_full	Detection and characterization of lung cancer using cell-free DNA fragmentomes
title_fullStr	Detection and characterization of lung cancer using cell-free DNA fragmentomes
title_full_unstemmed	Detection and characterization of lung cancer using cell-free DNA fragmentomes
title_sort	detection and characterization of lung cancer using cell-free dna fragmentomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fce9b8c82ce14c3ea1c846a1133812f2
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Detection and characterization of lung cancer using cell-free DNA fragmentomes

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