Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus

BACKGROUND AND OBJECTIVE: Systemic lupus disorder is a heterogeneous autoimmune disease that can affect any organ of the body. Leptin affects the activation, differentiation and proliferation of immune cells. This study aimed to evaluate the serum level of leptin and its relationship with disease ac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	MA Aghdashi, S Salami, A Hajian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	serum leptin systemic lupus erythematosus active phase inflammatory factors. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fcec5807a35f4444a63d69e4475b9586
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fcec5807a35f4444a63d69e4475b9586
record_format	dspace
spelling	oai:doaj.org-article:fcec5807a35f4444a63d69e4475b95862021-11-09T10:15:54ZEvaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus1561-41072251-7170https://doaj.org/article/fcec5807a35f4444a63d69e4475b95862020-03-01T00:00:00Zhttp://jbums.org/article-1-8913-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Systemic lupus disorder is a heterogeneous autoimmune disease that can affect any organ of the body. Leptin affects the activation, differentiation and proliferation of immune cells. This study aimed to evaluate the serum level of leptin and its relationship with disease activity and some inflammatory factors in women with systemic lupus erythematosus (SLE). METHODS: In this cross-sectional study, 40 women with SLE who were admitted to the rheumatology ward of Urmia Imam Khomeini Hospital during the second semester of 2017 and 40 healthy controls were enrolled. Serum leptin concentration was measured by sandwich ELISA method in two groups. In SLE patients the disease activity was calculated using Systematic lupus erythematous activity index (SLEDAI). Inflammatory factors including CRP (C-reactive protein) and ESR (Erythrocyte Sedimentation Rate) were extracted from the patient's records at the time of admission. FINDINGS: Serum leptin level was significantly different in patients (44.51±25.6) and controls (22.37±12.58) (p<0.001). Also, Serum leptin level was significantly higher in the active phase than inactive phase of the disease (active phase: 67.13±24.88, inactive phase: 24.88±12.37) (p<0.001). There was a positive correlation among serum leptin and activity level (r=0.7, p<0.001), ESR (r=0.53, p<0.001) and CRP (r=0.34, p=0.027). CONCLUSION: Leptin serum level is high in patients with systemic lupus erythematous and is positively associated with disease activity.MA AghdashiS SalamiA HajianBabol University of Medical Sciencesarticleserum leptinsystemic lupus erythematosusactive phaseinflammatory factors.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 156-161 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	serum leptin systemic lupus erythematosus active phase inflammatory factors. Medicine R Medicine (General) R5-920
spellingShingle	serum leptin systemic lupus erythematosus active phase inflammatory factors. Medicine R Medicine (General) R5-920 MA Aghdashi S Salami A Hajian Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
description	BACKGROUND AND OBJECTIVE: Systemic lupus disorder is a heterogeneous autoimmune disease that can affect any organ of the body. Leptin affects the activation, differentiation and proliferation of immune cells. This study aimed to evaluate the serum level of leptin and its relationship with disease activity and some inflammatory factors in women with systemic lupus erythematosus (SLE). METHODS: In this cross-sectional study, 40 women with SLE who were admitted to the rheumatology ward of Urmia Imam Khomeini Hospital during the second semester of 2017 and 40 healthy controls were enrolled. Serum leptin concentration was measured by sandwich ELISA method in two groups. In SLE patients the disease activity was calculated using Systematic lupus erythematous activity index (SLEDAI). Inflammatory factors including CRP (C-reactive protein) and ESR (Erythrocyte Sedimentation Rate) were extracted from the patient's records at the time of admission. FINDINGS: Serum leptin level was significantly different in patients (44.51±25.6) and controls (22.37±12.58) (p<0.001). Also, Serum leptin level was significantly higher in the active phase than inactive phase of the disease (active phase: 67.13±24.88, inactive phase: 24.88±12.37) (p<0.001). There was a positive correlation among serum leptin and activity level (r=0.7, p<0.001), ESR (r=0.53, p<0.001) and CRP (r=0.34, p=0.027). CONCLUSION: Leptin serum level is high in patients with systemic lupus erythematous and is positively associated with disease activity.
format	article
author	MA Aghdashi S Salami A Hajian
author_facet	MA Aghdashi S Salami A Hajian
author_sort	MA Aghdashi
title	Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
title_short	Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
title_full	Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
title_fullStr	Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
title_full_unstemmed	Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
title_sort	evaluation of serum leptin level and its association with disease activity and some inflammatory factors in systemic lupus erythematosus
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/fcec5807a35f4444a63d69e4475b9586
work_keys_str_mv	AT maaghdashi evaluationofserumleptinlevelanditsassociationwithdiseaseactivityandsomeinflammatoryfactorsinsystemiclupuserythematosus AT ssalami evaluationofserumleptinlevelanditsassociationwithdiseaseactivityandsomeinflammatoryfactorsinsystemiclupuserythematosus AT ahajian evaluationofserumleptinlevelanditsassociationwithdiseaseactivityandsomeinflammatoryfactorsinsystemiclupuserythematosus
_version_	1718441168484696064

Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus

Ejemplares similares