Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation

Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glyca...

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Auteurs principaux: Qingfei Zheng, Adewola Osunsade, Yael David
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/fced30f35c3c4c4fa7ad21938c03dc03
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Résumé:Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glycation.