Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation

Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glyca...

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Main Authors:	Qingfei Zheng, Adewola Osunsade, Yael David
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/fced30f35c3c4c4fa7ad21938c03dc03
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id	oai:doaj.org-article:fced30f35c3c4c4fa7ad21938c03dc03
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spelling	oai:doaj.org-article:fced30f35c3c4c4fa7ad21938c03dc032021-12-02T18:02:47ZProtein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation10.1038/s41467-020-17066-y2041-1723https://doaj.org/article/fced30f35c3c4c4fa7ad21938c03dc032020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17066-yhttps://doaj.org/toc/2041-1723Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glycation.Qingfei ZhengAdewola OsunsadeYael DavidNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingfei Zheng Adewola Osunsade Yael David Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
description	Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glycation.
format	article
author	Qingfei Zheng Adewola Osunsade Yael David
author_facet	Qingfei Zheng Adewola Osunsade Yael David
author_sort	Qingfei Zheng
title	Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
title_short	Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
title_full	Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
title_fullStr	Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
title_full_unstemmed	Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
title_sort	protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fced30f35c3c4c4fa7ad21938c03dc03
work_keys_str_mv	AT qingfeizheng proteinargininedeiminase4antagonizesmethylglyoxalinducedhistoneglycation AT adewolaosunsade proteinargininedeiminase4antagonizesmethylglyoxalinducedhistoneglycation AT yaeldavid proteinargininedeiminase4antagonizesmethylglyoxalinducedhistoneglycation
_version_	1718378906380140544

Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation

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