CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ

Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to und...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antonia Marcianò, Antonio Ieni, Rodolfo Mauceri, Giacomo Oteri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	medication-related osteonecrosis of the jaw angiogenesis surgical treatment treatment outcome Medicine R
Acceso en línea:	https://doaj.org/article/fced46d210ba40ffbf16f7b764bd3354
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fced46d210ba40ffbf16f7b764bd3354
record_format	dspace
spelling	oai:doaj.org-article:fced46d210ba40ffbf16f7b764bd33542021-11-11T16:29:34ZCD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ10.3390/ijerph1821113621660-46011661-7827https://doaj.org/article/fced46d210ba40ffbf16f7b764bd33542021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11362https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, “healed” and “not healed”. Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.Antonia MarcianòAntonio IeniRodolfo MauceriGiacomo OteriMDPI AGarticlemedication-related osteonecrosis of the jawangiogenesissurgical treatmenttreatment outcomeMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11362, p 11362 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	medication-related osteonecrosis of the jaw angiogenesis surgical treatment treatment outcome Medicine R
spellingShingle	medication-related osteonecrosis of the jaw angiogenesis surgical treatment treatment outcome Medicine R Antonia Marcianò Antonio Ieni Rodolfo Mauceri Giacomo Oteri CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
description	Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, “healed” and “not healed”. Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.
format	article
author	Antonia Marcianò Antonio Ieni Rodolfo Mauceri Giacomo Oteri
author_facet	Antonia Marcianò Antonio Ieni Rodolfo Mauceri Giacomo Oteri
author_sort	Antonia Marcianò
title	CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
title_short	CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
title_full	CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
title_fullStr	CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
title_full_unstemmed	CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
title_sort	cd34 and cd105 microvessels in resected bone specimen may implicate wound healing in mronj
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fced46d210ba40ffbf16f7b764bd3354
work_keys_str_mv	AT antoniamarciano cd34andcd105microvesselsinresectedbonespecimenmayimplicatewoundhealinginmronj AT antonioieni cd34andcd105microvesselsinresectedbonespecimenmayimplicatewoundhealinginmronj AT rodolfomauceri cd34andcd105microvesselsinresectedbonespecimenmayimplicatewoundhealinginmronj AT giacomooteri cd34andcd105microvesselsinresectedbonespecimenmayimplicatewoundhealinginmronj
_version_	1718432333603799040

CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ

Ejemplares similares