Resistance to Neuraminidase Inhibitors Conferred by an R292K Mutation in a Human Influenza Virus H7N9 Isolate Can Be Masked by a Mixed R/K Viral Population

Resistance to Neuraminidase Inhibitors Conferred by an R292K Mutation in a Human Influenza Virus H7N9 Isolate Can Be Masked by a Mixed R/K Viral Population

ABSTRACT We characterized the A/Shanghai/1/2013 virus isolated from the first confirmed human case of A/H7N9 disease in China. The A/Shanghai/1/2013 isolate contained a mixed population of R (65%; 15/23 clones) and K (35%; 8/23 clones) at neuraminidase (NA) residue 292, as determined by clonal seque...

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Main Authors: H.-L. Yen, J. L. McKimm-Breschkin, K.-T. Choy, D. D. Y. Wong, P. P. H. Cheung, J. Zhou, I. H. Ng, H. Zhu, R. J. Webby, Y. Guan, R. G. Webster, J. S. M. Peiris
Format: article
Language:EN
Published: American Society for Microbiology 2013
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/fced74dfee2944c2943e9fa6a7b2bde2
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