Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.

The habenula (Hb) has been hypothesized to play an essential role in major depressive disorder (MDD) as it is considered to be an important node between fronto-limbic areas and midbrain monoaminergic structures based on animal studies. In this study, we aimed to investigate the differences in volume...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seo-Eun Cho, Chan-A Park, Kyoung-Sae Na, ChiHye Chung, Hyo-Jin Ma, Chang-Ki Kang, Seung-Gul Kang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fcee7ceedeee4627b2b5cd699d38b99c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fcee7ceedeee4627b2b5cd699d38b99c
record_format	dspace
spelling	oai:doaj.org-article:fcee7ceedeee4627b2b5cd699d38b99c2021-12-02T20:15:18ZLeft-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.1932-620310.1371/journal.pone.0255459https://doaj.org/article/fcee7ceedeee4627b2b5cd699d38b99c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255459https://doaj.org/toc/1932-6203The habenula (Hb) has been hypothesized to play an essential role in major depressive disorder (MDD) as it is considered to be an important node between fronto-limbic areas and midbrain monoaminergic structures based on animal studies. In this study, we aimed to investigate the differences in volume and T1 value of the Hb between patients with MDD and healthy control (HC) subjects. Analysis for the Hb volumes was performed using high-resolution 7-T magnetic resonance (MR) image data from 33 MDD patients and 36 healthy subjects. Two researchers blinded to the clinical data manually delineated the habenular nuclei and Hb volume, and T1 values were calculated based on overlapping voxels. We compared the Hb volume and T1 value between the MDD and HC groups and compared the volume and T1 values between the left and right Hbs in each group. Compared to HC subjects, MDD patients had a smaller right Hb volume; however, there was no significant volume difference in the left Hb between groups. In the MDD group, the right Hb was smaller in volume and lower in T1 value than the left Hb. The present findings suggest a smaller right Hb volume and left-right asymmetry of Hb volume in MDD. Future high-resolution 7-T MR imaging studies with larger sample sizes will be needed to derive a more definitive conclusion.Seo-Eun ChoChan-A ParkKyoung-Sae NaChiHye ChungHyo-Jin MaChang-Ki KangSeung-Gul KangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255459 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seo-Eun Cho Chan-A Park Kyoung-Sae Na ChiHye Chung Hyo-Jin Ma Chang-Ki Kang Seung-Gul Kang Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
description	The habenula (Hb) has been hypothesized to play an essential role in major depressive disorder (MDD) as it is considered to be an important node between fronto-limbic areas and midbrain monoaminergic structures based on animal studies. In this study, we aimed to investigate the differences in volume and T1 value of the Hb between patients with MDD and healthy control (HC) subjects. Analysis for the Hb volumes was performed using high-resolution 7-T magnetic resonance (MR) image data from 33 MDD patients and 36 healthy subjects. Two researchers blinded to the clinical data manually delineated the habenular nuclei and Hb volume, and T1 values were calculated based on overlapping voxels. We compared the Hb volume and T1 value between the MDD and HC groups and compared the volume and T1 values between the left and right Hbs in each group. Compared to HC subjects, MDD patients had a smaller right Hb volume; however, there was no significant volume difference in the left Hb between groups. In the MDD group, the right Hb was smaller in volume and lower in T1 value than the left Hb. The present findings suggest a smaller right Hb volume and left-right asymmetry of Hb volume in MDD. Future high-resolution 7-T MR imaging studies with larger sample sizes will be needed to derive a more definitive conclusion.
format	article
author	Seo-Eun Cho Chan-A Park Kyoung-Sae Na ChiHye Chung Hyo-Jin Ma Chang-Ki Kang Seung-Gul Kang
author_facet	Seo-Eun Cho Chan-A Park Kyoung-Sae Na ChiHye Chung Hyo-Jin Ma Chang-Ki Kang Seung-Gul Kang
author_sort	Seo-Eun Cho
title	Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
title_short	Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
title_full	Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
title_fullStr	Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
title_full_unstemmed	Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.
title_sort	left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-t magnetic resonance imaging.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fcee7ceedeee4627b2b5cd699d38b99c
work_keys_str_mv	AT seoeuncho leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT chanapark leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT kyoungsaena leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT chihyechung leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT hyojinma leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT changkikang leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging AT seunggulkang leftrightasymmetricandsmallerrighthabenulavolumeinmajordepressivedisorderonhighresolution7tmagneticresonanceimaging
_version_	1718374623658115072

Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.

Ejemplares similares