PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES

Ketoprofen (KTP) is a widely used anti-inflammatory drug. In this paper the validity of a trained version of the Jouyban-Acree (J & A) model is evaluated to predict the solubility of KTP in ethanol + water cosolvent mixtures. The usefulness of the solubility log-linear equation proposed by Yalk...

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Autores principales:	Mauricio Gantiva, Alicia Yurquina, Fleming Martínez R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	ketoprofen ethanol water cosolvent mixtures Jouyban-Acree equation Yalkowsky-Roseman equation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/fcf46babe3f4428bbf4c2c16f1116753
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spelling	oai:doaj.org-article:fcf46babe3f4428bbf4c2c16f11167532021-11-19T04:14:51ZPERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES0121-40042145-2660https://doaj.org/article/fcf46babe3f4428bbf4c2c16f11167532009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/3017https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Ketoprofen (KTP) is a widely used anti-inflammatory drug. In this paper the validity of a trained version of the Jouyban-Acree (J & A) model is evaluated to predict the solubility of KTP in ethanol + water cosolvent mixtures. The usefulness of the solubility log-linear equation proposed by Yalkowsky and Roseman (Y & R) is also evaluated for the same drug in this cosolvent system. The solubility estimation is studied as a function of temperature and cosolvent composition. The J & A and Y & R models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. The calculated values by using both models deviate notoriously from experimental values in several cases. Mauricio GantivaAlicia YurquinaFleming Martínez R.Universidad de Antioquiaarticleketoprofenethanol water cosolvent mixturesJouyban-Acree equationYalkowsky-Roseman equation.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	ketoprofen ethanol water cosolvent mixtures Jouyban-Acree equation Yalkowsky-Roseman equation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	ketoprofen ethanol water cosolvent mixtures Jouyban-Acree equation Yalkowsky-Roseman equation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Mauricio Gantiva Alicia Yurquina Fleming Martínez R. PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
description	Ketoprofen (KTP) is a widely used anti-inflammatory drug. In this paper the validity of a trained version of the Jouyban-Acree (J & A) model is evaluated to predict the solubility of KTP in ethanol + water cosolvent mixtures. The usefulness of the solubility log-linear equation proposed by Yalkowsky and Roseman (Y & R) is also evaluated for the same drug in this cosolvent system. The solubility estimation is studied as a function of temperature and cosolvent composition. The J & A and Y & R models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. The calculated values by using both models deviate notoriously from experimental values in several cases.
format	article
author	Mauricio Gantiva Alicia Yurquina Fleming Martínez R.
author_facet	Mauricio Gantiva Alicia Yurquina Fleming Martínez R.
author_sort	Mauricio Gantiva
title	PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
title_short	PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
title_full	PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
title_fullStr	PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
title_full_unstemmed	PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES
title_sort	performance of the yalkowsky & roseman and jouyban & acree models estimating the solubility of ketoprofen in ethanol + water cosolvent mixtures
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/fcf46babe3f4428bbf4c2c16f1116753
work_keys_str_mv	AT mauriciogantiva performanceoftheyalkowskyrosemanandjouybanacreemodelsestimatingthesolubilityofketoprofeninethanolwatercosolventmixtures AT aliciayurquina performanceoftheyalkowskyrosemanandjouybanacreemodelsestimatingthesolubilityofketoprofeninethanolwatercosolventmixtures AT flemingmartinezr performanceoftheyalkowskyrosemanandjouybanacreemodelsestimatingthesolubilityofketoprofeninethanolwatercosolventmixtures
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PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES

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