CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS

Abstract. A group of 122 children, aged 7 to 16 year, with minor clinical forms of tuberculosis and infected with Toxoplasma gondii (T. gondii) and Epstein–Barr virus (EBV) was examined to evaluate the cytokine system. Immunoenzyme techniques were used to detect the presence IgM, IgA, IgG to T. gond...

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Autores principales:	A. V. Kalityn, T. I. Dolgikh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines toxoplasmosis epstein–barr virus tuberculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fcf90bcca83f47158abca0275f125677
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spelling	oai:doaj.org-article:fcf90bcca83f47158abca0275f1256772021-11-18T08:03:38ZCONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS1563-06252313-741X10.15789/1563-0625-2008-2-3-273-276https://doaj.org/article/fcf90bcca83f47158abca0275f1256772014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/171https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A group of 122 children, aged 7 to 16 year, with minor clinical forms of tuberculosis and infected with Toxoplasma gondii (T. gondii) and Epstein–Barr virus (EBV) was examined to evaluate the cytokine system. Immunoenzyme techniques were used to detect the presence IgM, IgA, IgG to T. gondii and EBV, as well as IL-1β, IL-1Ra, IL-4, IL-8, and IFNγ cytokines in blood. The patients were classified into three groups: (I) children with IgG to T. gondii, (II) children with IgM or IgA to T. gondii (active toxoplasmosis), (III) children with T. gondii-specific IgA and EBV-IgG-EA (active course of both toxoplasmosis and EBV infection). A comparison group (IV) consisted of TB-infected, T. gondii-seronegative patients without EBV-IgG-EA. A control group included thirty persons without evident disease. In groups I-III, a simultaneous and significant increase in IL-4 and spontaneous IFNγ contents was found, in comparison with controls. In group III, however, a 4-fold depression in IL-1β production was revealed against group IV, along with a 5.5-fold stimulation IFNγ production (as compared with controls). In groups I, II, IV, an inadequate hyperproduction of IL-1β and low IL-1Ra levels were shown. In the group III, a 3.4-fold and 5,5 fold IL-1Ra decrease were found, as compared, respectively, with group IV and control group. IL-8 content in groups I to III significantly exceeded control values (a 2.9 to 3-fold increase, with higher rates in group II). Hence, a direct inhibitory effect of EBV upon cell-mediated immunity should not be excluded under the conditions of TB-infection and active toxoplasmosis, thus further aggravating the immune dysfunction. (Med.Immunol., 2008, vol. 10, N 2-3, pp 273-276).A. V. KalitynT. I. DolgikhSPb RAACIarticlecytokinestoxoplasmosisepstein–barr virustuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 273-276 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines toxoplasmosis epstein–barr virus tuberculosis Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines toxoplasmosis epstein–barr virus tuberculosis Immunologic diseases. Allergy RC581-607 A. V. Kalityn T. I. Dolgikh CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
description	Abstract. A group of 122 children, aged 7 to 16 year, with minor clinical forms of tuberculosis and infected with Toxoplasma gondii (T. gondii) and Epstein–Barr virus (EBV) was examined to evaluate the cytokine system. Immunoenzyme techniques were used to detect the presence IgM, IgA, IgG to T. gondii and EBV, as well as IL-1β, IL-1Ra, IL-4, IL-8, and IFNγ cytokines in blood. The patients were classified into three groups: (I) children with IgG to T. gondii, (II) children with IgM or IgA to T. gondii (active toxoplasmosis), (III) children with T. gondii-specific IgA and EBV-IgG-EA (active course of both toxoplasmosis and EBV infection). A comparison group (IV) consisted of TB-infected, T. gondii-seronegative patients without EBV-IgG-EA. A control group included thirty persons without evident disease. In groups I-III, a simultaneous and significant increase in IL-4 and spontaneous IFNγ contents was found, in comparison with controls. In group III, however, a 4-fold depression in IL-1β production was revealed against group IV, along with a 5.5-fold stimulation IFNγ production (as compared with controls). In groups I, II, IV, an inadequate hyperproduction of IL-1β and low IL-1Ra levels were shown. In the group III, a 3.4-fold and 5,5 fold IL-1Ra decrease were found, as compared, respectively, with group IV and control group. IL-8 content in groups I to III significantly exceeded control values (a 2.9 to 3-fold increase, with higher rates in group II). Hence, a direct inhibitory effect of EBV upon cell-mediated immunity should not be excluded under the conditions of TB-infection and active toxoplasmosis, thus further aggravating the immune dysfunction. (Med.Immunol., 2008, vol. 10, N 2-3, pp 273-276).
format	article
author	A. V. Kalityn T. I. Dolgikh
author_facet	A. V. Kalityn T. I. Dolgikh
author_sort	A. V. Kalityn
title	CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
title_short	CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
title_full	CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
title_fullStr	CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
title_full_unstemmed	CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS
title_sort	contents of il-1β, il-ra, il-4, il-8 and ifnγ in the children with minor clinical forms of tuberculosis infected with toxoplasma gondii and epstein–barr virus
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/fcf90bcca83f47158abca0275f125677
work_keys_str_mv	AT avkalityn contentsofil1bilrail4il8andifnginthechildrenwithminorclinicalformsoftuberculosisinfectedwithtoxoplasmagondiiandepsteinbarrvirus AT tidolgikh contentsofil1bilrail4il8andifnginthechildrenwithminorclinicalformsoftuberculosisinfectedwithtoxoplasmagondiiandepsteinbarrvirus
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CONTENTS OF IL-1Β, IL-RA, IL-4, IL-8 AND IFNΓ IN THE CHILDREN WITH MINOR CLINICAL FORMS OF TUBERCULOSIS INFECTED WITH TOXOPLASMA GONDII AND EPSTEIN–BARR VIRUS

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