TRPA1 Expression and Pathophysiology in Immune Cells

The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and mechano-sensing. However, in this review we illustrate how this channel is expressed also in cells of the immune system. TRPA1 has bee...

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Autores principales:	Robbe Naert, Alejandro López-Requena, Karel Talavera
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TRPA1 eosinophils basophils macrophages mast cells NK cells Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fcf9dfab0aff4bda8c08df7cb9e75e38
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spelling	oai:doaj.org-article:fcf9dfab0aff4bda8c08df7cb9e75e382021-11-11T16:55:27ZTRPA1 Expression and Pathophysiology in Immune Cells10.3390/ijms2221114601422-00671661-6596https://doaj.org/article/fcf9dfab0aff4bda8c08df7cb9e75e382021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11460https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and mechano-sensing. However, in this review we illustrate how this channel is expressed also in cells of the immune system. TRPA1 has been detected, mainly with biochemical techniques, in eosinophils, mast cells, macrophages, dendritic cells, T cells, and B cells, but not in neutrophils. Functional measurements, in contrast, remain very scarce. No studies have been reported in basophils and NK cells. TRPA1 in immune cells has been linked to arthritis (neutrophils), anaphylaxis and atopic dermatitis (mast cells), atherosclerosis, renal injury, cardiac hypertrophy and inflammatory bowel disease (macrophages), and colitis (T cells). The contribution of TRPA1 to immunity is dual: as detector of cell stress, tissue injury, and exogenous noxious stimuli it leads to defensive responses, but in conditions of aberrant regulation it contributes to the exacerbation of inflammatory conditions. Future studies should aim at characterizing the functional properties of TRPA1 in immune cells, an essential step in understanding its roles in inflammation and its potential as therapeutic target.Robbe NaertAlejandro López-RequenaKarel TalaveraMDPI AGarticleTRPA1eosinophilsbasophilsmacrophagesmast cellsNK cellsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11460, p 11460 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRPA1 eosinophils basophils macrophages mast cells NK cells Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	TRPA1 eosinophils basophils macrophages mast cells NK cells Biology (General) QH301-705.5 Chemistry QD1-999 Robbe Naert Alejandro López-Requena Karel Talavera TRPA1 Expression and Pathophysiology in Immune Cells
description	The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and mechano-sensing. However, in this review we illustrate how this channel is expressed also in cells of the immune system. TRPA1 has been detected, mainly with biochemical techniques, in eosinophils, mast cells, macrophages, dendritic cells, T cells, and B cells, but not in neutrophils. Functional measurements, in contrast, remain very scarce. No studies have been reported in basophils and NK cells. TRPA1 in immune cells has been linked to arthritis (neutrophils), anaphylaxis and atopic dermatitis (mast cells), atherosclerosis, renal injury, cardiac hypertrophy and inflammatory bowel disease (macrophages), and colitis (T cells). The contribution of TRPA1 to immunity is dual: as detector of cell stress, tissue injury, and exogenous noxious stimuli it leads to defensive responses, but in conditions of aberrant regulation it contributes to the exacerbation of inflammatory conditions. Future studies should aim at characterizing the functional properties of TRPA1 in immune cells, an essential step in understanding its roles in inflammation and its potential as therapeutic target.
format	article
author	Robbe Naert Alejandro López-Requena Karel Talavera
author_facet	Robbe Naert Alejandro López-Requena Karel Talavera
author_sort	Robbe Naert
title	TRPA1 Expression and Pathophysiology in Immune Cells
title_short	TRPA1 Expression and Pathophysiology in Immune Cells
title_full	TRPA1 Expression and Pathophysiology in Immune Cells
title_fullStr	TRPA1 Expression and Pathophysiology in Immune Cells
title_full_unstemmed	TRPA1 Expression and Pathophysiology in Immune Cells
title_sort	trpa1 expression and pathophysiology in immune cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fcf9dfab0aff4bda8c08df7cb9e75e38
work_keys_str_mv	AT robbenaert trpa1expressionandpathophysiologyinimmunecells AT alejandrolopezrequena trpa1expressionandpathophysiologyinimmunecells AT kareltalavera trpa1expressionandpathophysiologyinimmunecells
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TRPA1 Expression and Pathophysiology in Immune Cells

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