NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks

Abstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are ass...

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Autores principales:	Joseph R. Scarpa, Peng Jiang, Vance D. Gao, Martha H. Vitaterna, Fred W. Turek, Andrew Kasarskis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fcfae50e25be41e6bc8196f655c447ac
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spelling	oai:doaj.org-article:fcfae50e25be41e6bc8196f655c447ac2021-12-02T14:37:29ZNREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks10.1038/s41598-021-86255-62045-2322https://doaj.org/article/fcfae50e25be41e6bc8196f655c447ac2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86255-6https://doaj.org/toc/2045-2322Abstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are associated with shared underlying cortical molecular networks in preclinical AD. We integrate multi-omics data from two extensive public resources, a human Alzheimer’s disease cohort from the Mount Sinai Brain Bank (N = 125) reflecting AD progression and a (C57BL/6J × 129S1/SvImJ) F2 mouse population in which NREM delta power was measured (N = 98). Two cortical gene networks, including a CLOCK-dependent circadian network, are associated with NREM delta power and AD tauopathy progression. These networks were validated in independent mouse and human cohorts. Identifying gene networks related to preclinical AD elucidate possible mechanisms associated with the early disease phase and potential targets to alter the disease course.Joseph R. ScarpaPeng JiangVance D. GaoMartha H. VitaternaFred W. TurekAndrew KasarskisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
description	Abstract Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia. We test the hypothesis that reduced NREM delta power and increased tauopathy are associated with shared underlying cortical molecular networks in preclinical AD. We integrate multi-omics data from two extensive public resources, a human Alzheimer’s disease cohort from the Mount Sinai Brain Bank (N = 125) reflecting AD progression and a (C57BL/6J × 129S1/SvImJ) F2 mouse population in which NREM delta power was measured (N = 98). Two cortical gene networks, including a CLOCK-dependent circadian network, are associated with NREM delta power and AD tauopathy progression. These networks were validated in independent mouse and human cohorts. Identifying gene networks related to preclinical AD elucidate possible mechanisms associated with the early disease phase and potential targets to alter the disease course.
format	article
author	Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis
author_facet	Joseph R. Scarpa Peng Jiang Vance D. Gao Martha H. Vitaterna Fred W. Turek Andrew Kasarskis
author_sort	Joseph R. Scarpa
title	NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
title_short	NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
title_full	NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
title_fullStr	NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
title_full_unstemmed	NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
title_sort	nrem delta power and ad-relevant tauopathy are associated with shared cortical gene networks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fcfae50e25be41e6bc8196f655c447ac
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NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks

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